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Novel Agonist TREM2 Monoclonal Antibodies Activate Syk-Associated Cell Signaling Pathways
(2023-04-25)
Triggering receptor expressed on myeloid cells 2 (TREM2), a protein expressed on the surface of microglia, is genetically linked to, and a therapeutic target for Alzheimer’s disease (AD). As a myeloid cell receptor, TREM2 ...
Identification of a Robust Antibody Modulator of CD33 in In Vitro Models
(2023-09-14)
CD33 is a sialic acid binding immunoglobulin-type lectin found on myeloid cells throughout the body, including microglia, the brain’s resident immune cells. CD33 has been implicated genetically in late-onset Alzheimer’s ...