Browsing by Title
Now showing items 20531-20550 of 56955
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The G-protein Alpha Subunit Gsα Is A Tumor Suppressor In Sonic Hedgehog-driven Medulloblastoma
(2014)Medulloblastoma, the most common malignant childhood brain tumor, exhibits distinct molecular subtypes and cellular origins. Genetic alterations driving medulloblastoma initiation and progression remain poorly understood. ... -
G-protein-coupled receptors regulate autophagy by ZBTB16-mediated ubiquitination and proteasomal degradation of Atg14L
(eLife Sciences Publications, Ltd, 2015)Autophagy is an important intracellular catabolic mechanism involved in the removal of misfolded proteins. Atg14L, the mammalian ortholog of Atg14 in yeast and a critical regulator of autophagy, mediates the production ... -
The G-protein–gated K+ channel, IKACh, is required for regulation of pacemaker activity and recovery of resting heart rate after sympathetic stimulation
(The Rockefeller University Press, 2013)Parasympathetic regulation of sinoatrial node (SAN) pacemaker activity modulates multiple ion channels to temper heart rate. The functional role of the G-protein–activated K+ current (IKACh) in the control of SAN pacemaking ... -
G-quadruplex structures contribute to the neuroprotective effects of angiogenin-induced tRNA fragments
(National Academy of Sciences, 2014) -
G-Squared Statistic for Detecting Dependence, Additive Modeling, and Calibration Concordance for Astrophysical Data
(2017-08-31)We present three topics in this thesis, G-squared statistic for independence testing as well as additive modeling, and calibration concordance by multiplicative shrinkage. Detecting dependence is a fundamental problem. ... -
G. W. Cottrell, Jr.: A memoir
(Harvard Library, 1998) -
G1 arrest and differentiation can occur independently of Rb family function
(Rockefeller University Press, 2010)The ability of progenitor cells to exit the cell cycle is essential for proper embryonic development and homeostasis, but the mechanisms governing cell cycle exit are still not fully understood. Here, we tested the requirement ... -
G11.92-061-MM2: A bonafide massive prestellar core?
(IOP Publishing, 2014)Core accretion models of massive star formation require the existence of stable massive starless cores, but robust observational examples of such objects have proven elusive. We report subarcsecond-resolution Submillimeter ... -
G11.92–0.61-MM2: A bonafide massive prestellar core?
(IOP Publishing, 2014)Core accretion models of massive star formation require the existence of stable massive starless cores, but robust observational examples of such objects have proven elusive. We report subarcsecond-resolution Submillimeter ... -
G3BP–Caprin1–USP10 complexes mediate stress granule condensation and associate with 40S subunits
(The Rockefeller University Press, 2016)Mammalian stress granules (SGs) contain stalled translation preinitiation complexes that are assembled into discrete granules by specific RNA-binding proteins such as G3BP. We now show that cells lacking both G3BP1 and ... -
GaAs Enhancement-Mode NMOSFETs Enabled by Atomic Layer Epitaxial \(La_{1.8}Y_{0.2}O_3\) as Dielectric
(Institute of Electrical and Electronics Engineers, 2013-02-04)We demonstrate high performance enhancement-mode (E-mode) GaAs NMOSFETs with an epitaxial gate dielectric layer of \(La_{1.8}Y_{0.2}O_3\) grown by atomic layer epitaxy (ALE) on GaAs(111)A substrates. A \(0.5-\mu m\)-gate-length ... -
GaAs/Al[sub 0.15]Ga[sub 0.85]As terahertz quantum cascade lasers with double-phonon resonant depopulation operating up to 172 K
(AIP Publishing, 2010)We report the design and performance of GaAs/Al0.15Ga0.85As terahertz quantum cascade lasers with double-phonon resonant depopulation and a vertical lasing transition. Devices were processed into gold-clad double-metal ... -
GABA\(_A\) Receptors Containing the \(\alpha\)2 Subunit Are Critical for Direction-Selective Inhibition in the Retina
(Public Library of Science, 2012)Far from being a simple sensor, the retina actively participates in processing visual signals. One of the best understood aspects of this processing is the detection of motion direction. Direction-selective (DS) retinal ... -
GABAA receptor signalling mechanisms revealed by structural pharmacology
(Springer Nature, 2019-01)Type-A -aminobutyric receptors (GABAARs) are ligand-gated chloride channels with a very rich pharmacology. Some of their modulators, including benzodiazepines and general anaesthetics, are among the most successful drugs ... -
GABAergic parafacial zone is a medullary slow–wave–sleep promoting center
(2014)Work in animals and humans suggest the existence of a slow–wave sleep (SWS) promoting/EEG synchronizing center in the mammalian lower brainstem. While sleep–active GABAergic neurons in the medullary parafacial zone (PZ) ... -
Gabriel Harvey's method of annotating his books
(Harvard Library, 1948) -
GADD45α and γ interaction with CDK11p58 regulates SPDEF protein stability and SPDEF-mediated effects on cancer cell migration
(Impact Journals LLC, 2016)The epithelium-specific Ets transcription factor, SPDEF, plays a critical role in metastasis of prostate and breast cancer cells. While enhanced SPDEF expression blocks migration and invasion, knockdown of SPDEF expression ... -
Gadflies (Virg. Geo. 3.146-148)
(Harvard University Press, 1982) -
GADIA: A Greedy Asynchronous Distributed Interference Avoidance Algorithm
(Institute of Electrical and Electronics Engineers, 2010)In this paper, the problem of distributed dynamic frequency allocation is considered for a canonical communication network, which spans several networks such as cognitive radio networks and digital subscriber lines (DSLs). ... -
Gadolinium-Based Nanoparticles and Radiation Therapy for Multiple Brain Melanoma Metastases: Proof of Concept before Phase I Trial
(Ivyspring International Publisher, 2016)Nanoparticles containing high-Z elements are known to boost the efficacy of radiation therapy. Gadolinium (Gd) is particularly attractive because this element is also a positive contrast agent for MRI, which allows for the ...