Gadolinium-Based Nanoparticles and Radiation Therapy for Multiple Brain Melanoma Metastases: Proof of Concept before Phase I Trial
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Author
Kotb, Shady
Lux, François
Appaix, Florence
Barbier, Emmanuel L.
Tran, Vu-Long
Plissonneau, Marie
Gehan, Hélène
Lefranc, Florence
Rodriguez-Lafrasse, Claire
Verry, Camille
Tillement, Olivier
Sancey, Lucie
Note: Order does not necessarily reflect citation order of authors.
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https://doi.org/10.7150/thno.14018Metadata
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Kotb, S., A. Detappe, F. Lux, F. Appaix, E. L. Barbier, V. Tran, M. Plissonneau, et al. 2016. “Gadolinium-Based Nanoparticles and Radiation Therapy for Multiple Brain Melanoma Metastases: Proof of Concept before Phase I Trial.” Theranostics 6 (3): 418-427. doi:10.7150/thno.14018. http://dx.doi.org/10.7150/thno.14018.Abstract
Nanoparticles containing high-Z elements are known to boost the efficacy of radiation therapy. Gadolinium (Gd) is particularly attractive because this element is also a positive contrast agent for MRI, which allows for the simultaneous use of imaging to guide the irradiation and to delineate the tumor. In this study, we used the Gd-based nanoparticles, AGuIX®. After intravenous injection into animals bearing B16F10 tumors, some nanoparticles remained inside the tumor cells for more than 24 hours, indicating that a single administration of nanoparticles might be sufficient for several irradiations. Combining AGuIX® with radiation therapy increases tumor cell death, and improves the life spans of animals bearing multiple brain melanoma metastases. These results provide preclinical proof-of-concept for a phase I clinical trial.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737727/pdf/Terms of Use
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