Browsing by Author "Bosch, Ronald"
Now showing items 1-20 of 26
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Antiretroviral Intensification and Valproic Acid Lack Sustained Effect on Residual HIV-1 Viremia or Resting CD4+ Cell Infection
Archin, Nancie M.; Cheema, Manzoor; Parker, Daniel; Wiegand, Ann; Bosch, Ronald J.; Coffin, John M.; Eron, Joseph; Cohen, Myron; Margolis, David M. (Public Library of Science, 2010)Background: Human immunodeficiency virus (HIV) infection that persists despite antiretroviral therapy (ART) is a daunting problem. Given the limited evidence that resting CD4+ T cell infection (RCI) is affected by the ... -
Brief Report: Relationship Among Viral Load Outcomes in HIV Treatment Interruption Trials
Treasure, Graham C.; Aga, Evgenia; Bosch, Ronald J.; Mellors, John W.; Kuritzkes, Daniel R.; Para, Michael; Gandhi, Rajesh T.; Li, Jonathan Z. (JAIDS Journal of Acquired Immune Deficiency Syndromes, 2016)Abstract: Viral load (VL) rebound timing and set point were analyzed in 235 participants undergoing analytic treatment interruption (ATI) in 6 AIDS Clinical Trials Group studies. There was no significant association between ... -
CD4 count at presentation for HIV care in the United States and Canada: Are those over 50 years more likely to have a delayed presentation?
Althoff, Keri N; Gebo, Kelly A; Gange, Stephen J; Klein, Marina B; Hogg, Robert S; Horberg, Michael A; Saag, Michael S; Kitahata, Mari M; Eron, Joseph J; Napravnik, Sonia; Rourke, Sean B; Rodriguez, Benigno; Sterling, Timothy R; Deeks, Steven G; Jacobson, Lisa P; Kirk, Gregory D; Collier, Ann C; Benson, Constance A; Silverberg, Michael J; Goedert, James J; McKaig, Rosemary G; Thorne, Jennifer; Rachlis, Anita; Moore, Richard D; Justice, Amy C; Brooks, John T.; Bosch, Ronald J.; Gill, M. John; Martin, Jeffery N. (BioMed Central, 2010)We assessed CD4 count at initial presentation for HIV care among ≥50-year-olds from 1997-2007 in 13 US and Canadian clinical cohorts and compared to <50-year-olds. 44,491 HIV-infected individuals in the North American AIDS ... -
CD4 trajectory adjusting for dropout among HIV-positive patients receiving combination antiretroviral therapy in an East African HIV care centre
Kiragga, Agnes N; Lok, Judith J; Musick, Beverly S; Bosch, Ronald J; Mwangi, Ann; Wools-Kaloustian, Kara K; Yiannoutsos, Constantin T (International AIDS Society, 2014)Objective: Estimates of CD4 response to antiretroviral therapy (ART) obtained by averaging data from patients in care, overestimate population CD4 response and treatment program effectiveness because they do not consider ... -
Cervical Cancer Epidemiology Among HIV-Infected Women in North America
D’Souza, Gypsyamber; Jing, Yuezhou; Strickler, Howard; Silverberg, Michael; Engels, Eric; Dubrow, Robert; Eron, Joseph; Gebo, Kelly; Hogg, Bob; Kitahata, Mari; Klein, Marina; Moore, Richard; Rourke, Sean; Abraham, Alison G; Bosch, Ronald J.; Brooks, John T.; Gill, M J (BioMed Central, 2010) -
Closing the Gap: Increases in Life Expectancy among Treated HIV-Positive Individuals in the United States and Canada
Samji, Hasina; Cescon, Angela; Hogg, Robert S.; Modur, Sharada P.; Althoff, Keri N.; Buchacz, Kate; Burchell, Ann N.; Cohen, Mardge; Gebo, Kelly A.; Gill, M. John; Justice, Amy; Kirk, Gregory; Klein, Marina B.; Korthuis, P. Todd; Martin, Jeff; Napravnik, Sonia; Rourke, Sean B.; Sterling, Timothy R.; Silverberg, Michael J.; Deeks, Stephen; Jacobson, Lisa P.; Bosch, Ronald J.; Kitahata, Mari M.; Goedert, James J.; Moore, Richard; Gange, Stephen J. (Public Library of Science, 2013)Background: Combination antiretroviral therapy (ART) has significantly increased survival among HIV-positive adults in the United States (U.S.) and Canada, but gains in life expectancy for this region have not been well ... -
Comparative Analysis of Measures of Viral Reservoirs in HIV-1 Eradication Studies
Eriksson, Susanne; Graf, Erin H.; Dahl, Viktor; Strain, Matthew C.; Yukl, Steven A.; Lysenko, Elena S.; Bosch, Ronald J.; Lai, Jun; Chioma, Stanley; Emad, Fatemeh; Abdel-Mohsen, Mohamed; Hoh, Rebecca; Hecht, Frederick; Hunt, Peter; Somsouk, Ma; Wong, Joseph; Johnston, Rowena; Siliciano, Robert F.; Richman, Douglas D.; O'Doherty, Una; Palmer, Sarah; Deeks, Steven G.; Siliciano, Janet D. (Public Library of Science, 2013)HIV-1 reservoirs preclude virus eradication in patients receiving highly active antiretroviral therapy (HAART). The best characterized reservoir is a small, difficult-to-quantify pool of resting memory CD4+ T cells carrying ... -
Continuing or Adding IL-2 in Patients Treated with Antiretroviral Therapy (ACTG Protocol A5051, a Rollover Trial of ACTG Protocol A328)
Bosch, Ronald J.; Pollard, Richard B; Landay, Alan; Aga, Evgenia; Fox, Lawrence; Mitsuyasu, Ronald (BioMed Central, 2010)Background: Effective antiretroviral therapy reduces HIV-1 RNA levels, improves CD4 T-cell counts, and lowers the risk of opportunistic infections and malignancies. Interleukin-2 (IL-2) has been shown to increase CD4 T-cell ... -
The Effect of Raltegravir Intensification on Low-level Residual Viremia in HIV-Infected Patients on Antiretroviral Therapy: A Randomized Controlled Trial
Margolis, David M.; Read, Sarah; Kallungal, Beatrice; Palmer, Sarah; Medvik, Kathy; Lederman, Michael M.; Jacobson, Jeffrey M.; Wiegand, Ann; Kearney, Mary; Coffin, John M.; Mellors, John W.; Eron, Joseph J.; Gandhi, Rajesh Tim; Zheng, Summer; Bosch, Ronald J.; Chan, Ellen S.L.; Alatrakchi, Nadia (Public Library of Science, 2010)Background: Most HIV-1-infected patients on effective antiretroviral therapy (ART) with plasma HIV-1 RNA levels below the detection limits of commercial assays have residual viremia measurable by more sensitive methods. ... -
Factors Associated with Mortality in HIV-Infected and Uninfected Patients with Pulmonary Tuberculosis
Mugusi, Ferdinand M; Mehta, Saurabh; Villamor, Eduardo; Urassa, Willy; Saathoff, Elmar; Bosch, Ronald J.; Fawzi, Wafaie W. (BioMed Central, 2009)Background: HIV has fuelled the TB epidemic in sub-Saharan Africa. Mortality in patients co-infected with TB and HIV is high. Managing factors influencing mortality in TB patients might help reducing it. This study ... -
HIV-1 RNA Levels and Antiretroviral Drug Resistance in Blood and Non-Blood Compartments from HIV-1–Infected Men and Women enrolled in AIDS Clinical Trials Group Study A5077
Kantor, Rami; Bettendorf, Daniel; Bosch, Ronald J.; Mann, Marita; Katzenstein, David; Cu-Uvin, Susan; D’Aquila, Richard; Frenkel, Lisa; Fiscus, Susan; Coombs, Robert (Public Library of Science, 2014)Background: Detectable HIV-1 in body compartments can lead to transmission and antiretroviral resistance. Although sex differences in viral shedding have been demonstrated, mechanisms and magnitude are unclear. We compared ... -
Innovations in nutrition education and global health: the Bangalore Boston nutrition collaborative
Kuriyan, Rebecca; Griffiths, Jeffrey K; Finkelstein, Julia L; Thomas, Tinku; Raj, Tony; Bosch, Ronald J; Kurpad, Anura V; Duggan, Christopher (BioMed Central, 2014)Background: India has a wide range of nutrition and health problems which require professionals with appropriate skills, knowledge and trans-disciplinary collaborative abilities to influence policy making at the national ... -
Iron Status Predicts Treatment Failure and Mortality in Tuberculosis Patients: A Prospective Cohort Study from Dar es Salaam, Tanzania
Isanaka, Sheila; Aboud, Said; Mugusi, Ferdinand; Bosch, Ronald J.; Willett, Walter C.; Spiegelman, Donna Lynn; Duggan, Christopher Paul; Fawzi, Wafaie W. (Public Library of Science, 2012)Background: Experimental data suggest a role for iron in the course of tuberculosis (TB) infection, but there is limited evidence on the potential effects of iron deficiency or iron overload on the progression of TB disease ... -
Multivitamin supplementation improves haematologic status in children born to HIV-positive women in Tanzania
Liu, Enju; Duggan, Christopher; Manji, Karim P; Kupka, Roland; Aboud, Said; Bosch, Ronald J; Kisenge, Rodrick R; Okuma, James; Fawzi, Wafaie W (International AIDS Society, 2013)Introduction: Anaemia is prevalent among children born to HIV-positive women, and it is associated with adverse effects on cognitive and motor development, growth, and increased risks of morbidity and mortality. Objective: ... -
OA011-05. TLR-mediated pDC responses to HIV-1 ligands
Chang, J; Kulkarni, Shashikant; Meier, Angela; Lindsay, RJ; Bazner, S; Lifson, JD; Bosch, Ronald J.; Carrington, M; Altfeld, Marcus (BioMed Central, 2009) -
Predictors and consequences of anaemia among antiretroviral-naïve HIV-infected and HIV-uninfected children in Tanzania
Chatterjee, Anirban; Bosch, Ronald J.; Kupka, Roland; Hunter, David J.; Msamanga, Gernard I; Fawzi, Wafaie W. (Cambridge University Press (CUP), 2009)Objective Predictors and consequences of childhood anaemia in settings with high HIV prevalence are not well known. The aims of the present study were to identify maternal and child predictors of anaemia among children ... -
Predictors of change in nutritional and hemoglobin status among adults treated for tuberculosis in Tanzania
Kawai, Kosuke; Villamor, E; Mugusi, F.M.; Saathoff, E.; Urassa, W.; Bosch, Ronald J.; Spiegelman, Donna Lynn; Fawzi, Wafaie W. (International Union Against Tuberculosis and Lung Disease, 2011)BACKGROUND Patients with tuberculosis (TB) often suffer from profound malnutrition. OBJECTIVE To examine the patterns and predictors of change in nutritional and hemoglobin status during and after TB treatment. ... -
Predictors of stunting, wasting, and underweight among Tanzanian children born to HIV-infected women
McDonald, Christine M.; Kupka, Roland; Manji, Karim P.; Okuma, James; Bosch, Ronald J.; Aboud, Said; Kisenge, Rodrick; Spiegelman, Donna Lynn; Fawzi, Wafaie W.; Duggan, Christopher Paul (2012)Background: Children born to HIV-infected women are susceptible to undernutrition, but modifiable risk factors and the time course of the development of undernutrition have not been well characterized. Objective: To identify ... -
Primary Antimicrobial Resistance among Mycobacterium Tuberculosis Isolates from HIV Seropositive and HIV Seronegative Patients in Dar es Salaam Tanzania
Urassa, Willy; Mugusi, Ferdinand; Villamor, Eduardo; Msamanga, Gernard; Moshiro, Candida; Bosch, Ronald J.; Saathoff, Elmar; Fawzi, Wafaie W. (BioMed Central, 2008)Background: The United Republic of Tanzania is one of the 22 high M. tuberculosis burden countries. Data collected between 2002 and 2007 indicate that the global prevalence of drug-resistant M. tuberculosis including MDR ... -
A randomized trial of multivitamin supplementation in children with tuberculosis in Tanzania
Mehta, Saurabh; Mugusi, Ferdinand M; Bosch, Ronald J.; Aboud, Said; Chatterjee, Anirban; Finkelstein, Julia L; Fataki, Maulidi; Kisenge, Rodrick; Fawzi, Wafaie W. (Springer Science + Business Media, 2011)Background Children with tuberculosis often have underlying nutritional deficiencies. Multivitamin supplementation has been proposed as a means to enhance the health of these children; however, the efficacy of such an ...