Factors Associated with Mortality in HIV-Infected and Uninfected Patients with Pulmonary Tuberculosis
![Thumbnail](/bitstream/handle/1/4578131/2779816.pdf.jpg?sequence=3&isAllowed=y)
View/ Open
Author
Mugusi, Ferdinand M
Mehta, Saurabh
Urassa, Willy
Saathoff, Elmar
Published Version
https://doi.org/10.1186/1471-2458-9-409Metadata
Show full item recordCitation
Mugusi, Ferdinand M., Saurabh Mehta, Eduardo Villamor, Willy Urassa, Elmar Saathoff, Ronald J. Bosch, and Wafaie W. Fawzi. 2009. Factors associated with mortality in HIV-infected and uninfected patients with pulmonary tuberculosis. BMC Public Health 9:409.Abstract
Background: HIV has fuelled the TB epidemic in sub-Saharan Africa. Mortality in patients co-infected with TB and HIV is high. Managing factors influencing mortality in TB patients might help reducing it. This study investigates factors associated with mortality including patients' HIV sero-status, CD4 cell count, laboratory, nutritional and demographic characteristics in AFB smear positive pulmonary TB patients. Methods: We studied 887 sputum smear positive PTB patients, between 18 and 65 years of age receiving standard 8 months anti-TB treatment. Demographic, anthropometric and laboratory data including HIV, CD4 and other tests were collected at baseline and at regular intervals. Patients were followed for a median period of 2.5 years. Results: Of the 887 participants, 155 (17.5%) died, of whom 90.3% (140/155) were HIV-infected, a fatality of 29.7% (140/471) compared to 3.6% (15/416) among HIV-uninfected. HIV infection, age, low Karnofsky score, CD4 cell counts and hemoglobin, high viral load, and oral thrush were significantly associated with high mortality in all patients. Conclusion: Mortality among HIV-infected TB patients is high despite the use of effective anti-TB therapy. Most deaths occur after successful completion of therapy, an indication that patients die from causes other than TB. HIV infection is the strongest independent predictor of mortality in this cohort.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2779816/pdf/Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAACitable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:4578131
Collections
- SPH Scholarly Articles [6362]
Contact administrator regarding this item (to report mistakes or request changes)