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Loss of Insulin Receptor Substrates 1 and 2 Suppresses Kras-Driven Non-Small Cell Lung Cancer
(2017-07-06)
Lung cancer remains the leading cause of cancer death worldwide, with non-small cell lung cancer (NSCLC) being the majority of diagnosed cases of lung cancer. Mutant KRAS is found in about 25% of all NSCLC and has proved ...
In Vivo Genetic Screening to Identify Mechanisms of Resistance to Cancer Immunotherapy
(2017-10-10)
Despite the dramatic clinical success of cancer immunotherapy with PD-1 checkpoint blockade, most patients do not experience sustained clinical benefit from treatment, suggesting that additional therapeutic strategies are ...
Formation of a Termination-Resistant RNA Polymerase Complex: Studies on the Phage 82 Q Protein
(2015-07-22)
Due to their early discovery, relative simplicity, and well-defined function, the Q antiterminator proteins of bacteriophage lambda and related lambdoid phages serve as a model for understanding how the elongation and ...
The Wnt5a-Ror Signaling Pathway in the Morphogenesis of the Embryo
(2015-07-13)
Embryonic development is orchestrated by relatively few conserved core developmental signaling pathways that are used reiteratively to grow, specify and shape all tissues in the body into their final functional forms. The ...
Mechanism and Function of Dendritic Self-Avoidance and Self/non-Self Discrimination in the Mammalian Nervous System
(2015-06-29)
Dendritic and axonal arbors of many neuronal types exhibit self-avoidance, a phenomenon in which branches repel each other. This process ensures that individual neurons cover all parts of their territory uniformly. Some ...
Function-Specific Serotonergic Neurons in the Control of Breathing and Body Temperature
(2015-10-05)
The control of respiration and body temperature involves neural circuits within the brainstem modulated by the neurotransmitter serotonin (5HT), though it is unclear precisely which serotonergic neurons are critical to ...
Synaptic Specificity and Plasticity in Parvalbumin-Basket Cell Circuits
(2015-09-29)
Inhibitory interneurons regulate experience-dependent plasticity across brain regions. Perisomatic inhibition by fast-spiking, parvalbumin-positive basket cells (PV-cells) is central to these processes, but which synapses ...
Zebrafish Models of Congenital Myopathy
(2015-08-31)
The congenital myopathies are a diverse group of inherited neuromuscular disorders that manifest as skeletal muscle weakness at birth or in infancy, and are classically defined by the predominant morphological features ...
The role of centriole biogenesis in control of brain size
(2015-08-24)
Mutations in several genes that encode centrosomal proteins dramatically decrease the size of the human brain, which is the largest in the primate lineage, but how the proteins encoded by these microcephaly (‘small brain’) ...
The Regulation of Immunological Processes by Peripheral Neurons
(2015-09-23)
The nervous system and the immune system are the primary sensory interfaces between the internal and external environment. They are responsible for recognizing, integrating, and responding to stimuli with the appropriate ...