dc.contributor.author | Masutomi, Kenkichi | |
dc.contributor.author | Possemato, Richard | |
dc.contributor.author | Wong, Judy Y. | |
dc.contributor.author | Currier, Jennifer L. | |
dc.contributor.author | Tothova, Zuzana | |
dc.contributor.author | Manola, Judith B. | |
dc.contributor.author | Ganesan, Shridar | |
dc.contributor.author | Lansdorp, Peter M. | |
dc.contributor.author | Collins, Kathleen | |
dc.contributor.author | Hahn, William C. | |
dc.date.accessioned | 2019-10-13T16:03:36Z | |
dc.date.issued | 2005 | |
dc.identifier.citation | Masutomi, K., R. Possemato, J. M. Y. Wong, J. L. Currier, Z. Tothova, J. B. Manola, S. Ganesan, P. M. Lansdorp, K. Collins, and W. C. Hahn. 2005. “The Telomerase Reverse Transcriptase Regulates Chromatin State and DNA Damage Responses.” Proceedings of the National Academy of Sciences 102 (23): 8222–27. doi:10.1073/pnas.0503095102. | |
dc.identifier.issn | 0027-8424 | |
dc.identifier.issn | 0744-2831 | |
dc.identifier.issn | 1091-6490 | |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:41542813 | * |
dc.description.abstract | Constitutive expression of telomerase prevents senescence and crisis by maintaining telomere homeostasis. However, recent evidence suggests that telomerase is dynamically regulated in normal cells and also contributes to transformation independently of net telomere elongation. Here, we show that suppression of the telomerase catalytic subunit [human telomerase reverse transcriptase (hTERT)] expression abrogates the cellular response to DNA double strand breaks. Loss of hTERT does not alter short-term telomere integrity but instead affects the overall configuration of chromatin. Cells lacking hTERT exhibit increased radiosensitivity, diminished capacity for DNA repair, and fragmented chromosomes, demonstrating that loss of hTERT impairs the DNA damage response. | |
dc.language.iso | en_US | |
dc.publisher | National Academy of Sciences | |
dash.license | LAA | |
dc.title | The telomerase reverse transcriptase regulates chromatin state and DNA damage responses | |
dc.type | Journal Article | |
dc.description.version | Version of Record | |
dc.relation.journal | Proceedings of the National Academy of Sciences of the United States of America | |
dash.depositing.author | Hahn, William C::31ef101c797e643e0dfa48f8bce1dc3c::600 | |
dc.date.available | 2019-10-13T16:03:36Z | |
dash.workflow.comments | 1Science Serial ID 89864 | |
dc.identifier.doi | 10.1073/pnas.0503095102 | |
dash.source.volume | 102;23 | |
dash.source.page | 8222 | |