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dc.contributor.authorMcGovern, Mark E.
dc.contributor.authorCanning, David
dc.date.accessioned2019-01-14T14:56:18Z
dc.date.issued2015-10-08
dc.identifier.citationMcGovern, Mark E., and David Canning. 2015. “Vaccination and All-Cause Child Mortality From 1985 to 2011: Global Evidence From the Demographic and Health Surveys.” American Journal of Epidemiology 182 (9): 791–98. https://doi.org/10.1093/aje/kwv125.en_US
dc.identifier.issn0002-9262en_US
dc.identifier.issn1476-6256en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:37989559*
dc.description.abstractBased on models with calibrated parameters for infection, case fatality rates, and vaccine efficacy, basic childhood vaccinations have been estimated to be highly cost effective. We estimated the association of vaccination with mortality directly from survey data. Using 149 cross-sectional Demographic and Health Surveys, we determined the relationship between vaccination coverage and the probability of dying between birth and 5 years of age at the survey cluster level. Our data included approximately 1 million children in 68,490 clusters from 62 countries. We considered the childhood measles, bacillus Calmette-Guerin, diphtheria-pertussis-tetanus, polio, and maternal tetanus vaccinations. Using modified Poisson regression to estimate the relative risk of child mortality in each cluster, we also adjusted for selection bias that resulted from the vaccination status of dead children not being reported. Childhood vaccination, and in particular measles and tetanus vaccination, is associated with substantial reductions in childhood mortality. We estimated that children in clusters with complete vaccination coverage have a relative risk of mortality that is 0.73 (95% confidence interval: 0.68, 0.77) times that of children in a cluster with no vaccinations. Although widely used, basic vaccines still have coverage rates well below 100% in many countries, and our results emphasize the effectiveness of increasing coverage rates in order to reduce child mortality.en_US
dc.language.isoen_USen_US
dc.publisherOxford University Press (OUP)en_US
dc.relation.isversionofhttps://academic.oup.com/aje/article-pdf/182/9/791/220983/kwv125.pdfen_US
dc.relation.hasversionhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4757942/pdf/kwv125.pdfen_US
dash.licenseMETA_ONLY
dc.titleVaccination and All-Cause Child Mortality From 1985 to 2011: Global Evidence From the Demographic and Health Surveysen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalAmerican Journal of Epidemiologyen_US
dash.depositing.authorCanning, David
dc.date.available2019-01-14T14:56:18Z
dash.workflow.comments1Science Serial ID 7805en_US
dc.identifier.doi10.1093/aje/kwv125
dc.source.journalAm. J. Epidemiol.
dash.source.volume182;9
dash.source.page791-798
dash.contributor.affiliatedCanning, David
dc.identifier.orcid0000-0003-4041-1229


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