A Trial of the Effect of Micronutrient Supplementation on Treatment Outcome, T Cell Counts, Morbidity, and Mortality in Adults with Pulmonary Tuberculosis
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Author
Mugusi, Ferdinand
Urassa, Willy
Saathoff, Elmar
Matsumoto, Kenji
Meydani, Simin N.
Published Version
https://doi.org/10.1086/587846Metadata
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Villamor, Eduardo, Ferdinand Mugusi, Willy Urassa, Ronald J. Bosch, Elmar Saathoff, Kenji Matsumoto, Simin N. Meydani, and Wafaie W. Fawzi. 2008. “A Trial of the Effect of Micronutrient Supplementation on Treatment Outcome, T Cell Counts, Morbidity, and Mortality in Adults with Pulmonary Tuberculosis.” J. Infect. Dis. 197 (11) (June): 1499–1505. doi:10.1086/587846.Abstract
BackgroundTuberculosis (TB) often coincides with nutritional deficiencies. The effects of micronutrient supplementation on TB treatment outcomes, clinical complications, and mortality are uncertain.
Methods
We conducted a randomized, double-blind, placebo-controlled trial of micronutrients (vitamins A, B complex, C, and E, as well as selenium) in Dar es Salaam, Tanzania. We enrolled 471 human immunodeficiency virus (HIV)–infected and 416 HIV-negative adults with pulmonary TB at the time of initiating chemotherapy and monitored them for a median of 43 months.
Results
Micronutrients decreased the risk of TB recurrence by 45% overall (95% confidence interval [CI], 7% to 67%; P = .02) and by 63% in HIV-infected patients (95% CI, 8% to 85%; P = .02). There were no significant effects on mortality overall; however, we noted a marginally significant 64% reduction of deaths in HIV-negative subjects (95% CI, −14% to 88%; P = .08). Supplementation increased CD3+ and CD4+ cell counts and decreased the incidence of extrapulmonary TB and genital ulcers in HIV-negative patients. Micronutrients reduced the incidence of peripheral neuropathy by 57% (95% CI, 41% to 69%; P < .001), irrespective of HIV status. There were no significant effects on weight gain, body composition, anemia, or HIV load.
Conclusions
Micronutrient supplementation could improve the outcome in patients undergoing TB chemotherapy in Tanzania.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2564793/Terms of Use
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