Androgen Receptor CAG Repeats and Body Composition Among Ariaal Men
View/ Open
Author
Campbell, Benjamin C.
Gray, Peter B.
Eisenberg, Dan T. A.
Sorenson, Michael D.
Published Version
https://doi.org/10.1111/j.1365-2605.2007.00825.xMetadata
Show full item recordCitation
Campbell, Benjamin C., Peter B. Gray, Dan T. A. Eisenberg, Peter Ellison, and Michael D. Sorenson. Forthcoming. Androgen receptor CAG repeats and body composition among Ariaal men. International Journal of Andrology.Abstract
To determine the population variation in the androgen receptor (AR) and its association with body composition in a subsistence population, we sampled 87 settled and 65 nomadic males ages 20+ among the Ariaal of northern Kenya. Anthropometric measures included height, body mass index, fat-free mass (FFM), upper arm muscle plus bone area (AMPBA), % body fat (%BF), suprailliac skinfold (SISF), and waist-to-hip ratio. Salivary testosterone (T) was determined from both morning (Am T) and afternoon (Pm T) samples. Hair roots were obtained for genotyping AR CAG repeat length. AR CAG repeat length did not vary between the two sub-groups (overall value = 22.6 ± 3.1). Multiple regression models, controlling for age and residence, indicate that Pm T was positively associated with all measures of body composition. AR CAG repeat length was a significant positive predictor of height, FFM, %BF, SISF and waist circumference. There was a significant negative Pm T by AR CAG repeat length interaction in predicting all anthropometric measures but AMPBA. These findings provide evidence for population variation in AR CAG repeat length and suggest that both T and AR CAG length play a role in body composition in this extremely lean population.Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAACitable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:2580545
Collections
- FAS Scholarly Articles [18295]
Contact administrator regarding this item (to report mistakes or request changes)