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Accessible Mutational Trajectories for the Evolution of Pyrimethamine Resistance in the Malaria Parasite Plasmodium Vivax
(Springer Science + Business Media, 2013)
Antifolate antimalarials, such as pyrimethamine, have experienced a dramatic reduction in therapeutic efficacy as resistance has evolved in multiple malaria species. We present evidence from one such species, Plasmodium ...
Malaria Life Cycle Intensifies Both Natural Selection and Random Genetic Drift
(Proceedings of the National Academy of Sciences, 2013)
Analysis of genome sequences of 159 isolates of Plasmodium falciparum from Senegal yields an extraordinarily high proportion (26.85%) of protein-coding genes with the ratio of nonsynonymous to synonymous polymorphism greater ...
Antagonists of Wnt and BMP signaling promote the formation of vertebrate head muscle
(Cold Spring Harbor Laboratory Press, 2003)
Recent studies have postulated that distinct regulatory cascades control myogenic differentiation in the head and the trunk. However, although the tissues and signaling molecules that induce skeletal myogenesis in the trunk ...
Kernel Intensity Estimation of 2-Dimensional Spatial Poisson Point Processes From k-Tree Sampling
(Springer Science + Business Media, 2014)
To estimate the spatial intensity (density) of plants and animals, ecologists often sample populations by prespecifing a spatial array of points, then measuring the distance from each point to the k nearest organisms, a ...
Paths Less Traveled: Evo-Devo Approaches to Investigating Animal Morphological Evolution
(Annual Reviews, 2012)
One of the chief aims of modern biology is to understand the causes and mechanisms of morphological evolution. Multicellular animals display a stunning diversity of shapes and sizes of their bodies and individual suborganismal ...
Roles for modularity and constraint in the evolution of cranial diversity among anolis lizards
(Wiley-Blackwell, 2011)
Complex organismal structures are organized into modules, suites of traits that develop, function, and vary in a coordinated fashion. By limiting or directing covariation among component traits, modules are expected to ...
Birds have paedomorphic dinosaur skulls
(Nature Publishing Group, 2012)
The interplay of evolution and development has been at the heart of evolutionary theory for more than a century. Heterochrony—change in the timing or rate of developmental events—has been implicated in the evolution of ...
Terrestrial biosphere models need better representation of vegetation phenology: results from the North American Carbon Program Site Synthesis
(Wiley Blackwell (Blackwell Publishing), 2012)
Phenology, by controlling the seasonal activity of vegetation on the land surface, plays a fundamental role in regulating photosynthesis and other ecosystem processes, as well as competitive interactions and feedbacks to ...
Triploid Plover Female Provides Support for a Role of the W Chromosome in Avian Sex Determination
(The Royal Society, 2012)
Two models, Z Dosage and Dominant W, have been proposed to explain sex determination in birds, in which males are characterized by the presence of two Z chromosomes, and females are hemizygous with a Z and a W chromosome. ...
Establishing criteria for higher-level classification using molecular data: the systematics ofPolyommatusblue butterflies (Lepidoptera, Lycaenidae)
(Wiley-Blackwell, 2012)
Most taxonomists agree on the need to adapt current classifications to recognize monophyletic units. However, delineations between higher taxonomic units can be based on the relative ages of different lineages and/or the ...