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Structural Basis of Colibactin Activation by the ClbP Peptidase
(Springer Science and Business Media LLC, 2022-10-17)
Colibactin, a DNA crosslinking agent produced by gut bacteria, is implicated in colorectal cancer. Its biosynthesis uses a prodrug resistance mechanism: a non-toxic precursor assembled in the cytoplasm is activated after ...
Improved green and red GRAB sensors for monitoring dopaminergic activity in vivo
(Springer Science and Business Media LLC, 2023-11-30)
Dopamine (DA) plays multiple roles in a wide range of physiological and pathological processes via a vast network of dopaminergic projections. To fully dissect the spatiotemporal dynamics of DA release in both dense and ...