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Prevention of Catch-Up Growth by Early-Life Postnatal Undernutrition causes Impaired Insulin Secretion and Glucose Metabolism on HFD
(2021-06-10)
Type 2 Diabetes (T2D) is a metabolic disease characterized by chronic elevation in plasma glucose levels.T2D affects millions of people worldwide. One risk factor for developing T2D is accelerated postnatal growth, or ...
Evaluation of the Novel Hevylite Immunoassay (HLC) in the Quantification of Monoclonal Proteins in Monoclonal Gammopathies.
(2021-08-20)
Quantification of the monoclonal protein (M-protein) in monoclonal gammopathies is crucial for correct diagnosis, management, and prognosis. When the M-protein concentration is less than 10 g/L, and it migrates to the ...
Addressing the Needs of Research and Clinical Applications for Cell-Free DNA, Exome Selection, and Targeted Panel Selection in a High-Throughput Laboratory Environment
(2021-10-20)
The thesis will address the development of a new targeted enrichment method using a hybrid selection-based approach. While targeted enrichment approaches have been used routinely by many research and clinical labs, the ...
Identifying Circulating MiRNAs as Potential Biomarkers for Kidney Disease by qRT-PCR
MicroRNAs (miRNAs) are short endogenous non-coding RNA molecules that play critical roles in gene regulation, cell differentiation, proliferation, apoptosis, and metabolism. MiRNA levels in blood and other body fluids are ...
Sex Hormones in Parkinson’s Disease
(2021-11-08)
The incidence of Parkinson’s disease (PD) is higher in the male population, and males are more likely to have earlier onset and more severe disease course, characterized by an akinetic-rigid phenotype with progression to ...
Viability of Biological Material Found in Sterilized Surgical Instrument Trays
(2022-05-12)
Viability of microorganisms left in surgical instrument trays after use is a challenging topic to observe. The following paper outlines a study conducted that reviewed two main components of the Sterile Processing Department ...
Characterization of Synthetic Reference Material for ctDNA Detection Assays
(2022-04-21)
Precision medicine is a fast-growing field within the cancer biotechnology industry that tailors a patient’s treatment to their specific biological makeup. Liquid biopsy offers a noninvasive, more heterogenous look into a ...
The Impact of Sleep Disturbances and Sleep Debt on Emotion Regulation and Reactivity in Obstructive Sleep Apnea Patients
(2022-05-23)
Sleep debt and disturbances are a growing problem worldwide, and the ramifications are unavoidable and detrimental to one’s physical health, mental health, and safety. Individuals diagnosed with Obstructive Sleep Apnea ...
MHC Class II Transactivator CIITA as a Potential Therapeutic Target for Amyotrophic Lateral Sclerosis
(2022-05-23)
The incidence of ALS is rising, and with onset of the disease usually occurring around 50-60 years of age, an effective treatment is urgent. Many of the proposed ALS pathogenic mechanisms, including neuroinflammation and ...
The Association of Steroid 5-Alpha Reductase Type 2 and Estrogen Receptors in the Prostate
(2021-05-14)
Benign prostatic hyperplasia (BPH) continues to remain a significant health problem. Steroid 5α-reductase 2 (SRD5A2) is the predominant enzyme responsible for prostatic development and growth. Our previous study demonstrated ...