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Now showing items 11-20 of 97
Screening Potential Treatments of Hepatocellular Carcinoma through Single-Cell RNA Sequencing and the Connectivity Map
(2022-12-08)
Hepatocellular carcinoma (HCC) is the most common form of liver cancer, which is the second most prevalent cause of cancer mortalities worldwide. The current standard of care for non-resectable HCC is to combine immunotherapy ...
Converting Conventional Antibodies into ScFv and ScFv-Fc Fusion Fragments to Improve Expression and Function
(2021-05-06)
Antibodies are used in many diagnostic, therapeutic, and research applications around the world. Traditionally, conventional full-length antibodies have been used for these applications, however, with the development of ...
Determining Synthetic Lethal Targets in DNA Polymerase Epsilon P286R Mutants Using Genome-wide CRISPR-Cas9 Knockout Screens
(2022-05-23)
Genomic instability is an important hallmark of cancer development and is often a product of impaired or abnormal DNA replication. For instance, DNA Polymerase Epsilon (POLE) is responsible for the bulk of DNA replication ...
Differentiating Human iPSCs into Dopaminergic Neurons that Express Classical Biochemical Traits and Show Neuronal Transmission and Excitability
(2022-05-12)
Parkinson’s disease (PD) is an incurable neurodegenerative disorder. Current therapeutic approaches are aimed to lessen the symptoms without slowing or halting the disease progression (Hammond, Constance et al., 2007). ...
Efficacy of HIV-1 Clade B Tat Protein Treatment of Experimental Autoimmune Neuritis in Rats
(2022-01-20)
This research was focused to investigate the use of Tat clade B for HIV-1 to treat Guillain-Barre Syndrome (GBS). This investigation was conducted with a Lewis rat model to induce experimental autoimmune neuritis (EAN) as ...
Media Optimization Results in the Retention of Long and Short-Term Hematopoietic Stem Cells in Zinc Finger Modified Healthy Donor CD34+ Cells
(2023-05-01)
Sickle Cell Disease (SCD) is a genetic disease effecting millions of people around the world. SCD is the result of a point mutation in the beta-globin chain of hemoglobin which causes glutamic acid to be replaced with ...
Development of Solvent Free, in situ Cross-linked Biodegradable Nanofibers Using Rotary Jet Spinning
(2022-06-15)
Currently, there is a pressing and growing need for the development of biodegradable and sustainable nonwoven materials. Nonwoven fabrics are designed to be disposal, non-durable materials that are predominantly single use ...
Noninvasive Translational Approaches to Study the Disease Pathogenesis of Patients with Atopic Dermatitis
(2021-08-20)
Atopic dermatitis (AD) is a chronic or acute inflammatory skin condition that affects many children and adults and can be severe and debilitating. It is characterized by itchy, dry, red, flaky skin and it is caused by ...
Impact of Fish Feeding Habitat and Diet on Microplastic Concentrations in Gastrointestinal Tracts of St. Lawrence River Fish
(2022-10-11)
Approximately 370 million tons of plastic are being produced annually (Plastics Europe, 2020). Only a small portion is recycled due to poor waste management practices. An estimated eight million tons of plastic moves from ...
Synthesis of Proteolysis Targeting Chimera Components with Pedagogical Applications for the Teaching–Research Nexus
(2021-05-24)
Proteolysis targeting chimeras (PROTACs) exploit endogenous cellular ubiquitination mechanisms to selectively degrade proteins by initiating complexation between ubiquitin ligases and target substrates. Immunomodulatory ...