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Comparative Assessment of SARS-CoV-2 Diagnostics in Nigeria
(2024-01-16)
Viral pandemics are a major threat to public health, as they have the potential to overwhelm health systems and cause a significant loss of lives and economic meltdown. The COVID-19 pandemic highlighted not only the impact ...
Enhancing Tissue Integrity for Improved Robustness of Multiplexed Fluorescent Imaging
(2024-01-24)
Tissue-based cyclic immunofluorescence, or t-CyCIF (hereafter referred to as “CyCIF”), accomplishes iterative multiplexing of fluorescent markers by diminishing active fluorophores with an oxidizing solution capable of ...
Drug Resistance Amplification in Tuberculosis: Integrating Drug Sensitivity Testing with Whole Genome Sequencing
(2024-01-03)
Tuberculosis (TB), a disease caused by Mycobacterium tuberculosis (Mtb), remains a global health threat, presenting significant challenges to effective treatment due to the emergence of drug-resistant strains. The prevalence ...
Genetic Expression Assessment of N6-Methyladenosine (m6A) in Relation to Migraine Remission After Pregnancy
(2024-01-16)
Migraine is a complex neurological disorder with its cause most likely stemming from polygenic and environmental factors (Aczél et al., 2021; Vetvik & MacGregor, 2021). Migraine attacks involve the activation of the ...
Drug-Responsive Regulation and Comparison of Engineered Transcription Factors Containing Different Activation Domains
(2024-01-08)
The pursuit of effective tools for probing biological systems has led to a growing
interest in approaches that offer both rapid, reversible, and accurate methods.
Specifically, the ability to perturb the function of specific ...
Recommendations for Improving the Diagnostic Criteria for Mast Cell Activation Syndrome
(2024-01-02)
Mast Cell Activation Syndrome (MCAS) is a disorder in which patients experience a wide variety of frequently debilitating allergic reactions and symptoms. The onset can be sudden, and it is often a life-changing disorder ...
Use of the Zebrafish to Explore the Connection of Pituitary Development with Congenital Craniofacial Syndromes
(2024-05-06)
This thesis project analyzes pituitary development using the zebrafish study model. Our lab focuses on studying craniofacial malformations using complementary models that include human and other mammalian cells, mice and ...
Episodic Liver Injuries Lead to a Long-Term Liver Damage and Molecular Changes
(2024-05-09)
The liver is the biggest organ in the body that contributes to many vital functions like metabolism, immunity, digestion, and detoxification. The liver is not only capable of regenerating itself after a chemical or surgical ...
The Branch Point in Medium- to Large-Size Introns and its Contribution to the Splicing Process in the Model Organism C. elegans
(2024-05-09)
RNA splicing, an important co-transcriptional change in many eukaryotes, involves processing pre-mRNA before it exits the nucleus to either translate into proteins or function as RNA. This splicing crucially includes ...
A Framework for The Study of Compound Interactions in L1000
(2024-05-09)
Treatment combinations are used broadly in clinical settings and are used to treat a variety of diseases and disorders. Despite the potential power of combination therapies to improve the lives of more patients, the complete ...