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How Many Moralities? a Bottom-Up Approach to Mapping the Brain’s Natural Moral Categories
(2015-10-07)
The external structure and internal boundaries of the moral domain are not sharply defined. Substantive definitions of morality struggle to cleanly encapsulate the full diversity of human moral concern without including ...
Spatial Organization of Local Inputs to Spiny Projection Neurons in the Striatum
(2015-10-19)
GABAergic interneurons are important for balanced activity of the principal projection neurons of the striatum (spiny projection neurons, SPNs) and dysfunction of striatal GABAergic interneurons can lead to movement-related ...
Examining the Anti-Inflammatory Characteristics of Translocator Protein Through IL-10 Modulation
(2015-10-20)
Several central nervous system related diseases involve various cellular inflammation related components. Among others these components include increases in complement activation and synthesis of inflammatory signaling ...
Progressive Changes in MOR1 in the Striatum of the Heterozygous Q175 Knock-in Mouse Model of Huntington's Disease
(2016-03-21)
Huntington’s disease (HD) is a progressive autosomal dominant neurodegenerative disease that produces pronounced neurodegeneration of neostriatal neurons as well as cortical neurons in HD patients. Despite the fact that ...
An Interactive Deep Learning Toolkit for Automatic Segmentation of Images
(2016-06-25)
This thesis presents the design, analysis, and implementation of an interactive deep learning toolkit to reduce the manual labeling effort and improve the automatic segmentation of image data. While deep neural networks ...
Development of a New Uniform File Format for Neuroscience Data Across the Globe
(2016-05-02)
With about 1011 neurons and about 1015 synaptic connections the human brain is among the most complex biologic systems ever observed (Rautenberg, Sobolev et al. 2011). Technical progress is driving the volume of data ...
The Dynamics of Hypothalamic Cell Proliferation in Mice
(2016-10-16)
Adult neurogenesis is the process by which new neurons are generated by neural stem cells (NSC) and are integrated into existing neural circuits in the adult brain. Contemporary research in adult neurogenesis in mammals ...
Utilizing Brain Tumor Microenvironment to Propagate Pediatric Pilocytic Astrocytoma in Vitro and Test Novel Targeted Drug Therapies
(2018-04-09)
Pediatric brain tumors have recently surpassed leukemia as the leading cause of cancer related death in children (American Brain Tumor Association). Pilocytic astrocytoma (PA) is the most common type of primary central ...
Characterization of the Effects of IVIg on CNS Inflammation Leading to Non-Classical Disease in a Relapsing Remitting Model of EAE
(2016-10-19)
Intravenous Immunoglobulin (IVIg) is a complex therapeutic used in the treatment of multiple autoimmune and inflammatory diseases. The mechanism of action of IVIg is pleiotropic; there is increasing evidence that modulation ...
Decreased Expression of the Protein Orhodenticle Homeobox 2 (Otx2) in Individuals With Schizophrenia: A Postmortem Investigation
(2016-06-22)
The purpose of this thesis was to determine if the amount of the protein Orthodenticle homeobox 2 (Otx2) is reduced in individuals with schizophrenia. Otx2 is a transcription factor that plays an essential role in the ...