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Assessing the Mutational Landscape of BRAF- and KRAS-Wild Type Colorectal Cancer
(2018-02-28)
Colorectal cancer is one of the most deadly cancers and is the second leading cause of death in the United States. As incidence of colorectal cancer is higher among developed countries, research continues in hopes to make ...
Acoustic Characteristics of Phonological Development in a Juvenile African Grey Parrot (Psittacus Erithacus) Who Is Learning Referential Speech
(2015-10-06)
Although young children can sometimes produce words in a near perfect form at a very early stage, several diary studies revealed that these correct first productions are usually followed by less faithful renditions, only ...
Spatial Organization of Local Inputs to Spiny Projection Neurons in the Striatum
(2015-10-19)
GABAergic interneurons are important for balanced activity of the principal projection neurons of the striatum (spiny projection neurons, SPNs) and dysfunction of striatal GABAergic interneurons can lead to movement-related ...
Financial Analysis of Biosimilar Development Candidates: A Case Study on the US Biosimilar Business
(2015-10-20)
This case study investigates the US biosimilar business and the approach that should be implemented when financially analyzing biosimilar development candidates. To challenge the theory that the biosimilar business will ...
A Role for DOCK4 in Intestinal Barrier Properties
(2016-02-16)
Restoration of epithelial and endothelial barrier function is critical for tissue homeostasis. Yet, the molecular pathways response for modulating barrier properties remains largely unknown. This study investigates the ...
Establishing Novel Immunoaffinity Purification Methods for Fusion Proteins
(2016-03-31)
The experiments in this thesis were performed to determine if novel uses of three fusion proteins could be established as a means of improving the protein purification process, and in particular, the elution step, thus ...
Creatine Assay for Use on Bench Top Chemistry Analyzer: Quick Analysis of Creatine in Human Serum Smaples
(2016-05-02)
Creatine (Cr) was initially discovered in the 1830s by a Frenchman named Chevreul. In subsequent years, it was discovered that creatine was utilized by the musculatory system, which fueled research on its overall use as a ...
Determining the Feasibility of a Liposomal Prototype Formulation for GC-C Agonist Peptide Drug Delivery
(2016-05-02)
The purpose of this study was to determine the feasibility of using a liposomal formulation for the systemic delivery of a GC-C agonist peptide drug. Peptide drugs have increased in numbers lately but are limited by ...
IgA Antibody Responses to Borrelia Burgdorferi and Three Specific Autoantigens in Patients With Lyme Disease: Correlations With Cytokine Mediators and Disease Duration
(2017-05-13)
The aim of this research was to investigate IgA antibody responses to Borrelia burgdorferi and 3 related autoantigens in patients with early manifestations of Lyme disease, including those with erythema migrans (EM) and ...
A Revised Biosocial Analysis to Social Suffering: Reframing a Paradigm on Mental Health for Palestinians Living Under Trauma
(2018-04-17)
The goal of this research is to shed light on the chronic, systematic violence that the Palestinians endure on a daily basis using a different approach from the Western model of PTSD and war trauma. The Palestinians have ...