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Examining the Anti-Inflammatory Characteristics of Translocator Protein Through IL-10 Modulation
(2015-10-20)
Several central nervous system related diseases involve various cellular inflammation related components. Among others these components include increases in complement activation and synthesis of inflammatory signaling ...
A Role for DOCK4 in Intestinal Barrier Properties
(2016-02-16)
Restoration of epithelial and endothelial barrier function is critical for tissue homeostasis. Yet, the molecular pathways response for modulating barrier properties remains largely unknown. This study investigates the ...
Evaluation of Cellular Mechanisms Involved in Recombinant Antibody Expression in Transiently Transfected Chinese Hamster Ovary Cells
(2016-05-02)
Transient recombinant antibody production in Chinese hamster ovary (CHO) cells is often used to screen large panels of candidates for potential therapeutic use. However, a significant proportion of antibodies express at a ...
A Novel Diagnostic Approach to Screen for Chemotherapy Drug Response in Non-Small Cell Lung Cancer Using Sortase Technology
(2016-05-02)
Drug resistance is the most significant barrier to improving long-term outcomes for patients with non-small cell lung cancer (NSCLC). Recent advances in the understanding of cell biology and molecular pathways have enabled ...
Pooled shRNA Library Screening to Identify Enhancers of Lysosomal Exocytosis
(2016-05-02)
Lysosomal exocytosis results in the removal of the lysosomal content by fusion of the lysosome with the plasma membrane, simultaneously relocating the lysosomal marker LAMP1 to the cell surface. Enhancing lysosomal exocytosis ...
Differential Function of in Vitro Generated Macrophages From Systemic Lupus Erythematosus and Non-Diseased Peripheral Blood Mononuclear Cells
(2016-05-02)
Macrophages are a major type of tissue resident phagocytic cell that help orchestrate the innate immune response (through recognition to highly conserved pathogens) as well as facilitate the adaptive immune response (through ...
Utilizing Brain Tumor Microenvironment to Propagate Pediatric Pilocytic Astrocytoma in Vitro and Test Novel Targeted Drug Therapies
(2018-04-09)
Pediatric brain tumors have recently surpassed leukemia as the leading cause of cancer related death in children (American Brain Tumor Association). Pilocytic astrocytoma (PA) is the most common type of primary central ...
Characterization of the Effects of IVIg on CNS Inflammation Leading to Non-Classical Disease in a Relapsing Remitting Model of EAE
(2016-10-19)
Intravenous Immunoglobulin (IVIg) is a complex therapeutic used in the treatment of multiple autoimmune and inflammatory diseases. The mechanism of action of IVIg is pleiotropic; there is increasing evidence that modulation ...
The Effects of Down-Regulation of MZB1 Expression on Apoptosis in Chronic Lymphocytic Leukemia B Cells With Mutations in the Splicing Factor 3b-1 Protein
(2017-02-02)
The goal of this work was to explore the role of the B cell specific Marginal Zone B and B1 cell (MZB1) protein in B cell viability and apoptosis with relation to mutations Splicing Factor 3B subunit 1 (SF3B1) protein, one ...
Methods for Measuring Ciliary Calcium Dynamics: Potential Role for the Ciliary Inversin Compartment
(2017-03-28)
The primary cilium is a cellular organelle at the nexus of many human disease syndromes that include polycystic kidney disease (PKD), embryonic developmental defects and retinal degeneration. While the whole organism ...