Browsing DCE Theses and Dissertations by Keyword "Nanotechnology"
Now showing items 1-13 of 13
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A Review of CITE-Seq Best Practices in the CAR-T Landscape
(2023-04-25)The purpose of this study was to determine a set of best practices for analyzing CITE-seq data, particularly in the context of CAR-T therapies. To determine the best method of denoising protein expression data, multiple ... -
ATHERO52, A Proof of Concept Device Design to Remove and Treat Atherosclerosis with a Non-Invasive Surgical Approach
(2021-05-24)Atherosclerosis, associated with coronary artery disease (CAD) contributes to one of the largest reasons for deaths worldwide in 2017 (Center for Disease Control and Prevention [CDC], 2019a). Commercialized devices on ... -
CardiP: A Proof-of-Concept Design of Transdermal Delivery of a Diuretic with Nanoparticles for Congestive Heart Failure
(2023-10-11)Heart Failure (HF) is a medical condition that affects more than 6 million people in the United States with healthcare costs gradually rising with the readmission of each heart failure patient. Therefore, feasible solutions ... -
Characterization of Dietary Patterns, Cognitive Function, and Mood in Diverse Populations of Cardiac Patients in the age of Covid-19
(2024-01-18)Global health has been significantly impacted by the COVID-19 pandemic, and cardiovascular disease is no exception. This research indicates that adhering to the MIND diet may lessen complications connected to heart disease, ... -
Designing self-amplifying replicons for transient gene expression of interleukin-18
(2021-05-14)RNA-based therapeutics are on the rise as a re-emerging technology bolstered by the SARS-CoV-2 pandemic. However, issues such as storage, protein expression, and delivery are major challenges for the broad applicability. ... -
Developing the Next Generation Rapid Diagnostic Microfluidic Devices for Measuring the Protein Levels in Multiple Myeloma Patients for Early Detection of Disease Re-Appearance
(2021-05-14)The objective of this research is to determine whether rapid diagnostics paper microfluidic devices can be easily fabricated in the lab and be viable for in house testing, for multiple myeloma patients. Numerous paper ... -
Identifying Vulnerabilities and Novel Drug Candidates in Platinum-Resistant Ovarian Cancer.
(2024-05-09)Ovarian cancer is the fifth leading cause of female, cancer-related death in the United States and the deadliest form of gynecological cancer (Cancer Facts & Figures 2022, 2022). Epithelial ovarian cancer (EOC) accounts ... -
Intratumoral, multiplexed and polymer-assisted dosing of drugs as a new method for assessment of efficacy of new oncology drug candidates or drug combinations.
(2023-10-16)Motivated by the global toll of cancer-related health issues and death, this work identifies some of the key issues facing the pharmaceutical development industry and presents a technological solution to these challenges. ... -
Maximum Mismatch between Six-Residue Sequences of SARS-CoV-2 Spike Proteins and Human Proteome
(2023-12-13)A first step toward finding effective antivirals for Covid-19 may be the identification of immunogenic, conserved, short and accessible epitopes on the surface molecules of human coronavirus. An important requirement, ... -
Nanoparticle Clearance: A Regulatory Summary Recommending Strengthening of the Current FDA Guidance in Assuring Long Term Safety of Nanoparticle Therapies in Cancer Patients
(2023-05-01)Cancer has complicated pathogenesis, making it one of the leading causes of mortality and morbidity. Traditional cancer treatments include targeted therapy, immunotherapy, chemotherapy, and radiation therapy. The development ... -
Precise Correction of A1AT E342K by Modified NGA PAM Prime Editing and Determination of Prime Editing Inhibition by TREX2
(2021-10-15)The purpose of this research is to evaluate the potential of the CRISPR-derived class of prime editors for precise correction of the E342K mutation in Alpha-1 Antitrypsin Deficiency (A1AD) and to discover genetic dependencies ... -
Purification of Mammalian Vimentin via the Reassembly of BJ5TAa IF Method
(2023-04-28)The protein vimentin is an intermediate filament and is part of the cytoskeleton in cells and tissues. The cytoskeleton is comprised of three total protein-based components that undergo liquid-liquid phase separation ... -
Twins, Complications and Vaginal Delivery: Vaginal vs. Cesarean Section Deliveries and Opportunities for Improvement
(2021-05-06)With the rise in twins born each year, there is an increased concern with how to ensure twin delivery is conducted safely for both mother and infants (CDC, 1998, 2015, 2017). A gestation that has multiple fetuses can lead ...