Browsing DCE Theses and Dissertations by Keyword "Knockout Screen"
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Determining Synthetic Lethal Targets in DNA Polymerase Epsilon P286R Mutants Using Genome-wide CRISPR-Cas9 Knockout Screens
(2022-05-23)Genomic instability is an important hallmark of cancer development and is often a product of impaired or abnormal DNA replication. For instance, DNA Polymerase Epsilon (POLE) is responsible for the bulk of DNA replication ...