Browsing DCE Theses and Dissertations by Keyword "CAR-T"
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A Comparison of Co-stimulatory HVEM Domains in Second Generation CAR-T Cells
(2022-10-05)Chimeric antigen receptor T cells (CAR-T) are T cells that have been genetically modified to express a receptor that recognizes a specific target molecule. When T cells bind to their target molecule, usually a surface ... -
Formulaic Definition of the Strength of a Gene-Edited EGFR CAR-T Drug Product
(2021-05-14)The goal of this work was to define a relative formulaic potency score for use in autologous chimeric antigen receptor (CAR)-T drug products (DP), as an alternative to the use of absolute potency reporting of identity, ...