Browsing DCE Theses and Dissertations by Keyword "A1AD"
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Precise Correction of A1AT E342K by Modified NGA PAM Prime Editing and Determination of Prime Editing Inhibition by TREX2
(2021-10-15)The purpose of this research is to evaluate the potential of the CRISPR-derived class of prime editors for precise correction of the E342K mutation in Alpha-1 Antitrypsin Deficiency (A1AD) and to discover genetic dependencies ...