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Plant-based diets and risk of erectile dysfunction in young men
(2021-05-14)
Erectile dysfunction (ED) is the most common medical issue associated with aging. Beyond the obvious impact on sexual quality of life, data suggests that ED may be an early indicator cardiometabolic disease. In fact, ...
Evaluating the Severity of an Unconditioned Stimulus in PTSD
(2023-04-27)
The current study investigated relationships between the severity of Posttraumatic Stress Disorder (PTSD) symptoms and the magnitude of the unconditioned response (UR) to an unconditioned aversive stimulus (US) as well ...
Waking Experience and Circadian Rhythms Result in Differential Modulation of Sleep and Wake States
(2021-10-15)
Sleep is thought to be tightly regulated by two processes, a homeostatic and a circadian process, which interact in a complex way to integrate prior wakefulness and circadian time (Borbély et al., 1982). Despite extensive ...
Investigating Fibroblast Activation State and Phenotype in Tumor Co-culture Models
(2022-05-12)
Fibroblast cells in the tumor microenvironment play a role in cancer cell growth, progression of invasion, and secretion of extracellular matrix components, cytokines, and growth factors. Characterizing fibroblast subsets ...
Phenotypical and Functional Characterization of Prenylcysteine Oxidase 1 Like (Pcyox1l) Knockout Murine Neutrophils.
(2022-10-11)
Prenylcysteine oxidase 1 like (Pcyox1l) is a known protein coding gene where the protein has no described function. To examine the role of Pcyox1l on murine neutrophil function and metabolism, in vitro and in vivo experiments ...
Investigating the Effects of IgA Antibodies Elicited by Active Immunization against Clostridiodes difficile on Disease Progression and Severity in Mice
(2023-04-25)
Currently, there is no licensed vaccine against Clostridioides difficile. This study explores whether inducing mucosal immune responses (i.e., IgA antibodies), via immunization with C. difficile vaccine candidates may have ...
Discovery of SOX10 as a Key Pharmacodynamic Marker of BRM/BRG1 Inhibition in Uveal Melanoma
(2021-05-24)
Epigenetic dysregulation plays a fundamental role in the development of cancer. Chromatin remodeling complexes are major epigenetic modifiers, and defects in its activity has emerged as an important feature causing aberrant ...
A Systematic Gene List Comparison Maps the Complex Continuum of Molecular Events in Alzheimer’s Disease
(2023-05-05)
Current research on Alzheimer’s disease (AD) predominantly focuses on targeting beta-amyloid (Aß) plaques, as these are thought to be the initiators of disease. Approaching AD by focusing on Aß has led to limited therapeutic ...
Systematic Investigation into Endoriftia Flagellar System Suggests Possibility of System Co-Option for Additional Functionality
(2021-06-15)
The overarching goal of this study is to contribute to the development of the Candidatus Endoriftia persephone-Riftia pachyptila symbiotic association as a biological model system with a more specific goal being to ...
PacBio: Long Read Sequencing Capability for Whole Genome Sequencing
(2021-10-20)
The advancement in cameras and computation ability has allowed the sequencing industry to make revolutionary progress. One of the latest sequencing technologies, called “Third generation sequencing”, relies on the reading ...