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Identifying Circulating MiRNAs as Potential Biomarkers for Kidney Disease by qRT-PCR
MicroRNAs (miRNAs) are short endogenous non-coding RNA molecules that play critical roles in gene regulation, cell differentiation, proliferation, apoptosis, and metabolism. MiRNA levels in blood and other body fluids are ...
Novel Agonist TREM2 Monoclonal Antibodies Activate Syk-Associated Cell Signaling Pathways
(2023-04-25)
Triggering receptor expressed on myeloid cells 2 (TREM2), a protein expressed on the surface of microglia, is genetically linked to, and a therapeutic target for Alzheimer’s disease (AD). As a myeloid cell receptor, TREM2 ...
The Effect of Long-Duration Spaceflight on DNA Methylation of Longevity-Related Genes in a One-Year Astronaut Study
(2021-05-14)
The aging global population presents one of the most significant challenges of the 21st century, precipitating humanitarian, economic, and environmental burdens. Space provides a unique environment for studying longevity ...
Revealing Ancestral Arachnid Genes by Tracking Acetylcholinesterase Evolution in Spiders
(2023-10-19)
Acetylcholinesterase (AChE) is a vital enzyme which plays a key role in
regulation of neurotransmission in spiders and other animals. Because it is of critical
importance, this protein is targeted by many toxins, including ...
Comparative Assessment of SARS-CoV-2 Diagnostics in Nigeria
(2024-01-16)
Viral pandemics are a major threat to public health, as they have the potential to overwhelm health systems and cause a significant loss of lives and economic meltdown. The COVID-19 pandemic highlighted not only the impact ...