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Screening Potential Treatments of Hepatocellular Carcinoma through Single-Cell RNA Sequencing and the Connectivity Map
(2022-12-08)
Hepatocellular carcinoma (HCC) is the most common form of liver cancer, which is the second most prevalent cause of cancer mortalities worldwide. The current standard of care for non-resectable HCC is to combine immunotherapy ...
Addressing the Needs of Research and Clinical Applications for Cell-Free DNA, Exome Selection, and Targeted Panel Selection in a High-Throughput Laboratory Environment
(2021-10-20)
The thesis will address the development of a new targeted enrichment method using a hybrid selection-based approach. While targeted enrichment approaches have been used routinely by many research and clinical labs, the ...
An Analysis of How Lead Induces Changes in Histone Modification Levels that Impact Alzheimer’s Disease Gene Expression
(2023-05-03)
The goal of this study was to determine if lead exposure induced a histone epigenomic profile like that of Alzheimer’s Disease (AD) in differentiated SH-SY5Y neuroblastoma cells. AD is a neurological disease expressed as ...
Comparative Phylogeography of the Northern Australian Monsoon Tropics by Whole Genome Resequencing of two Species of the Avian Genus Climacteris
(2021-05-14)
Abstract
Phylogeography combines geographic information with phylogenetic analysis to gain insight into the origin, dispersal, and speciation dynamics of populations. Advances in the utility of Next Generation Sequencing ...
The Effect of Long-Duration Spaceflight on DNA Methylation of Longevity-Related Genes in a One-Year Astronaut Study
(2021-05-14)
The aging global population presents one of the most significant challenges of the 21st century, precipitating humanitarian, economic, and environmental burdens. Space provides a unique environment for studying longevity ...
Genetic and Pharmacological Investigations into a Zebrafish Model of ADPKD
(2021-05-24)
This research aimed to identify molecular mechanisms underlying autosomal dominant polycystic kidney disease (ADPKD) using genetic and pharmacological approaches in a zebrafish model of ADPKD. Specifically, our goal was ...
Investigating the Role of The Antioxidant N-acetylcarnosine in Attenuating Oxidation-induced Retinal Damage in Retinitis Pigmentosa
(2021-09-14)
The goal of this research was to explore the strong antioxidant, n-acetylcarnosine, in its capacity to ameliorate oxidative stress, specifically in the context of slowing disease progression of retinal degeneration. Retinal ...
Whole Genome Investigation of Genomic Aberrations of Rare Genetic Conditions Using Joint Analysis
(2023-10-11)
Genomic analysis is a method designed to assign meaning to the nucleotides of
DNA and translate them into readable information. The decreasing cost and increasing
efficiency of genomic sequencing have enabled the integration ...
Use of the Zebrafish to Explore the Connection of Pituitary Development with Congenital Craniofacial Syndromes
(2024-05-06)
This thesis project analyzes pituitary development using the zebrafish study model. Our lab focuses on studying craniofacial malformations using complementary models that include human and other mammalian cells, mice and ...