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Using Cyclic Immunofluorescence (CyCIF), Deep-learning, and Human Tumor Microarrays (hTMAs) for Antibody Validation and Creation of an Atlas of Cancers Emphasizing Unique Phenotypes
(2023-01-10)
All cancers are different from each other, in their mutation spectrum, primary location of occurrence, and metastases as well as their phenotypic traits and tumor composition. For years, clinicians and pathologists have ...
A Novel Framework for Medical Learning: Using AI Based Grad-CAM for Improving Otitis Media Diagnosis
(2023-01-10)
Otitis Media (OM) and its sub-categories of pathology are the number one pathology in children. Diagnosis is very difficult as it requires visual inspection the tympanic membrane of a child, which is in view for only a few ...
Investigation of Microplastics from Deep-Sea Antarctic and West Coast North American Sediments
(2023-01-23)
Microplastics have been found to be widespread and pervasive across marine
ecosystems. There is growing body of literature to indicate that microplastics are globally
distributed, including in deep sea sediments, yet there ...
Bioproduction of D-Tagatose in Escherichia coli by Harnessing the Reverse Leloir Pathway
(2023-01-11)
D-Tagatose is a natural, rare monosaccharide containing 38% of the calories of sucrose. As an alternative sweetener, it offers numerous benefits including a low glycemic index, prebiotic properties, and the ability to lower ...
Ecological Factors and Jaw Morphology in Lepidosauria: A Geometric Morphometric and Biomechanical Approach
(2023-04-20)
Lepidosauria consists of two reptilian orders, with squamates, the larger of the orders, consisting of about 11,000 species and are widespread globally. As a group, lepidosaurs are very diverse in habitat, leg development, ...
Media Optimization Results in the Retention of Long and Short-Term Hematopoietic Stem Cells in Zinc Finger Modified Healthy Donor CD34+ Cells
(2023-05-01)
Sickle Cell Disease (SCD) is a genetic disease effecting millions of people around the world. SCD is the result of a point mutation in the beta-globin chain of hemoglobin which causes glutamic acid to be replaced with ...
Evaluating the Severity of an Unconditioned Stimulus in PTSD
(2023-04-27)
The current study investigated relationships between the severity of Posttraumatic Stress Disorder (PTSD) symptoms and the magnitude of the unconditioned response (UR) to an unconditioned aversive stimulus (US) as well ...
Investigating the Effects of IgA Antibodies Elicited by Active Immunization against Clostridiodes difficile on Disease Progression and Severity in Mice
(2023-04-25)
Currently, there is no licensed vaccine against Clostridioides difficile. This study explores whether inducing mucosal immune responses (i.e., IgA antibodies), via immunization with C. difficile vaccine candidates may have ...
A Systematic Gene List Comparison Maps the Complex Continuum of Molecular Events in Alzheimer’s Disease
(2023-05-05)
Current research on Alzheimer’s disease (AD) predominantly focuses on targeting beta-amyloid (Aß) plaques, as these are thought to be the initiators of disease. Approaching AD by focusing on Aß has led to limited therapeutic ...
An Investigation into the Genetic and Bacterial Factors That Cause Irritable Bowel Syndrome and a Solution in the Form of a Targeted Next Generation Sequencing Compatible Gene Panel for the Disease.
(2023-05-01)
Irritable Bowel Syndrome (IBS) is a prevalent disease without complete
mechanistic understanding. Medical doctors and scientists alike do not know the cause
for the disease and therefore have trouble accurately diagnosing ...