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Identifying Non-canonical, Keap1-independent Regulators of Nrf2 Degradation in Non-small Cell Lung Cancer
(2022-12-21)
Nrf2 (nuclear factor erythroid 2-related factor 2) is a transcription factor responsible for cellular antioxidant response to oxidative and electrophilic stress. Keap1 (Kelch ECH associating protein 1) has been demonstrated ...
Understanding Fat Cadherins from an Evolutionary and Contextual Point of View
(2022-01-06)
Fat cadherins are an essential planar cell polarity molecule that is conserved throughout evolution. Yet little is known about what regions of these molecules has been conserved over time. This thesis describes the importance ...
Screening Potential Treatments of Hepatocellular Carcinoma through Single-Cell RNA Sequencing and the Connectivity Map
(2022-12-08)
Hepatocellular carcinoma (HCC) is the most common form of liver cancer, which is the second most prevalent cause of cancer mortalities worldwide. The current standard of care for non-resectable HCC is to combine immunotherapy ...
Determining Synthetic Lethal Targets in DNA Polymerase Epsilon P286R Mutants Using Genome-wide CRISPR-Cas9 Knockout Screens
(2022-05-23)
Genomic instability is an important hallmark of cancer development and is often a product of impaired or abnormal DNA replication. For instance, DNA Polymerase Epsilon (POLE) is responsible for the bulk of DNA replication ...
Differentiating Human iPSCs into Dopaminergic Neurons that Express Classical Biochemical Traits and Show Neuronal Transmission and Excitability
(2022-05-12)
Parkinson’s disease (PD) is an incurable neurodegenerative disorder. Current therapeutic approaches are aimed to lessen the symptoms without slowing or halting the disease progression (Hammond, Constance et al., 2007). ...
Efficacy of HIV-1 Clade B Tat Protein Treatment of Experimental Autoimmune Neuritis in Rats
(2022-01-20)
This research was focused to investigate the use of Tat clade B for HIV-1 to treat Guillain-Barre Syndrome (GBS). This investigation was conducted with a Lewis rat model to induce experimental autoimmune neuritis (EAN) as ...
Development of Solvent Free, in situ Cross-linked Biodegradable Nanofibers Using Rotary Jet Spinning
(2022-06-15)
Currently, there is a pressing and growing need for the development of biodegradable and sustainable nonwoven materials. Nonwoven fabrics are designed to be disposal, non-durable materials that are predominantly single use ...
Impact of Fish Feeding Habitat and Diet on Microplastic Concentrations in Gastrointestinal Tracts of St. Lawrence River Fish
(2022-10-11)
Approximately 370 million tons of plastic are being produced annually (Plastics Europe, 2020). Only a small portion is recycled due to poor waste management practices. An estimated eight million tons of plastic moves from ...
Investigating Fibroblast Activation State and Phenotype in Tumor Co-culture Models
(2022-05-12)
Fibroblast cells in the tumor microenvironment play a role in cancer cell growth, progression of invasion, and secretion of extracellular matrix components, cytokines, and growth factors. Characterizing fibroblast subsets ...
Phenotypical and Functional Characterization of Prenylcysteine Oxidase 1 Like (Pcyox1l) Knockout Murine Neutrophils.
(2022-10-11)
Prenylcysteine oxidase 1 like (Pcyox1l) is a known protein coding gene where the protein has no described function. To examine the role of Pcyox1l on murine neutrophil function and metabolism, in vitro and in vivo experiments ...