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Investigation of Antibody Response to Anaplasma phagocytophilum Immunodominant Targets During Early Phase Seroconversion in Cats and Dogs from Europe
(2023-12-13)
Abstract
Anaplasmosis is a tick-borne infection caused by the bacterium Anaplasma
phagocytophilum, transmitted by Ixodes spp. ticks. It infects humans and a wide variety
of domestic and wild animals worldwide. Anaplasmosis ...
Predict Non-Targeted Clearance of Therapeutic Antibodies Using a Human FcRn Dependent in vitro Transcytosis Assay
(2024-05-13)
The advancement in the protein engineering of therapeutic antibodies has enhanced biologic treatments of antibody-based proteins. The industry is evolving from monoclonal immunoglobulin (IgG) format to IgG antibody-based ...
Investigating the Effects of Mycobacterium tuberculosis Bacterial Heterogeneity on Innate Immune Cell Tropism
(2024-05-13)
Tuberculosis (TB) is an infectious disease caused by the pathogen Mycobacterium tuberculosis (Mtb). Tuberculosis is the leading cause of death by a single infectious agent worldwide despite the use of a live attenuated ...
Hydrocarbon-Degrading Bacteria and Potential Symbiosis with Deep-Sea Organisms: Using Ctenophores as a Model
(2024-05-13)
Microbiomes and the functions of microbes as they relate to their host have been of interest in many areas of research. Microbes have been of great interest in the deep sea as they serve as potential symbionts for the ...
Exploring the role of four Kazald paralogs in Axolotl limb regeneration
(2024-05-13)
This study aimed to establish the foundation for understanding a broader inquiry into whether other Kazald paralogs function as compensatory mechanisms for the Kazald2 gene, recognized for its upregulated in blastema and ...
Evaluation of Cre Recombinase Models for the Study of Dnmt3a Mutations and Myeloid Bias in Clonal Hematopoiesis
(2024-05-14)
The process of aging has been found to have lasting effects on hematopoietic stem cells and their ability to maintain the homeostasis of the hematopoietic system. From the accumulation of DNA damage to the biased differentiation ...
Assessment of Metabolism and Circadian Rhythm in Frontotemporal Dementia Using a Drosophila melanogaster Animal Model
(2024-05-14)
Abstract
The purpose of this behavioral study was to establish proofs of concept in metabolism and circadian rhythm in Frontotemporal Dementia (FTD) using a Drosophila melanogaster animal model that had been genetically ...
Spatiotemporal Reassortment of Th1 Migratory Receptors in Inflamed Skin
(2024-05-15)
CD4+ T helper (Th) cells search a vast tissue area to find sites of infection or inflammation. The distribution of Th cells in tissues is shaped by tissue architecture, chemotactic cues, adhesion molecules, and the location ...
Effect of Genetic Knockout and Pharmacological Inhibition of Galectin-3 on Alveolar Type 2 Cell Differentiation in Organoids
(2024-05-16)
Chronic respiratory diseases present a large medical and economic burden on the industrialized world, only overshadowed by heart disease and cancer. These diseases result in punctuated lung injury and repair cycles with a ...
Addressing the pharmacogenomic variance associated with infertility outcomes in south Asians and recommendations for customization of assisted reproductive technology techniques.
(2024-05-16)
Female subfertility impacts approximately 15% of the world population. Those experiencing infertility rely on Assisted Reproductive Technologies (ART), which constitutes a variety of procedures including In Vitro Fertilization ...