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Now showing items 11-20 of 23
Viability of Biological Material Found in Sterilized Surgical Instrument Trays
(2022-05-12)
Viability of microorganisms left in surgical instrument trays after use is a challenging topic to observe. The following paper outlines a study conducted that reviewed two main components of the Sterile Processing Department ...
Characterization of Synthetic Reference Material for ctDNA Detection Assays
(2022-04-21)
Precision medicine is a fast-growing field within the cancer biotechnology industry that tailors a patient’s treatment to their specific biological makeup. Liquid biopsy offers a noninvasive, more heterogenous look into a ...
The Impact of Sleep Disturbances and Sleep Debt on Emotion Regulation and Reactivity in Obstructive Sleep Apnea Patients
(2022-05-23)
Sleep debt and disturbances are a growing problem worldwide, and the ramifications are unavoidable and detrimental to one’s physical health, mental health, and safety. Individuals diagnosed with Obstructive Sleep Apnea ...
MHC Class II Transactivator CIITA as a Potential Therapeutic Target for Amyotrophic Lateral Sclerosis
(2022-05-23)
The incidence of ALS is rising, and with onset of the disease usually occurring around 50-60 years of age, an effective treatment is urgent. Many of the proposed ALS pathogenic mechanisms, including neuroinflammation and ...
Characterizing the Specificity and Cross-Reactivity Profile of the B Cell Response to Dengue Virus Serotype 2
(2022-10-11)
Dengue is a Flavivirus transmitted by Aedes mosquitoes, which causes significant disease burden worldwide (Michlmayr et al., 2021). Dengue disease can vary in severity from asymptomatic to potentially deadly dengue hemorrhagic ...
Role of mTORC1 in BDK-Mediated Improvements in Cardiometabolic Parameters
(2022-04-21)
Multiple recent studies from various labs have shown improvements in several endpoints in pre-clinical models after treatment with the branched chain ketoacid dehydrogenase kinase (BDK) inhibitor BT2, yet there is still a ...
Downstream Process Development for an Adeno-associated Virus Generated from HeLa Cell Line
(2022-07-06)
The goal of this work was to assemble a downstream purification process for
adeno-associated virus (AAV) gene therapy product utilizing a HeLa cell line in
Ultragenyx. HeLa cells were grown by upstream team and transfected ...
Pcyox1L Controls Immune Dynamics through Neutrophil Differentiation and Functionality
(2022-01-20)
Autophagy is a cellular function that is essential in maintaining homeostasis at the molecular level. Over the years, autophagy has defined its role in neutrophil biology and innate immunity. Understanding the role of ...
Using the CRISPR-Cas9 System Analogous to Restriction Enzymes Whose Recognition Site is 23 Nucleotides to Alter Pooled CRISPR Libraries
(2022-02-07)
Pooled CRISPR libraries in recent years have been widely used to perform genetic screens. Such a library contains tens of thousands of single guide RNA (sgRNA) constructs that target a set of genes of interest. A perfect ...
Utilization of High Throughput CRISPR Knockout Technologies to Identify Cellular Genes Involved in Human Papillomavirus Degradation of p53
(2022-05-10)
High-risk human papillomaviruses (hrHPVs) are the causative agents for most cases of cervical cancer; they have also been linked to other anogenital cancers as well as head and neck cancers. Vaccines against HPV were ...