dc.contributor.author | Kazani, Shamsah | en_US |
dc.contributor.author | Arm, Jonathan P | en_US |
dc.contributor.author | Boyce, Joshua | en_US |
dc.contributor.author | Chhay, Heng | en_US |
dc.contributor.author | Dutile, Stefanie | en_US |
dc.contributor.author | Wechsler, Michael E | en_US |
dc.contributor.author | Govindarajulu, Usha | en_US |
dc.contributor.author | Ivester, Priscilla | en_US |
dc.contributor.author | Ainsworth, Hannah C | en_US |
dc.contributor.author | Sergeant, Susan | en_US |
dc.contributor.author | Chilton, Floyd H | en_US |
dc.contributor.author | Israel, Elliot | en_US |
dc.date.accessioned | 2015-01-05T18:28:28Z | |
dc.date.issued | 2014 | en_US |
dc.identifier.citation | Kazani, S., J. P. Arm, J. Boyce, H. Chhay, S. Dutile, M. E. Wechsler, U. Govindarajulu, et al. 2014. “LTC4 synthase polymorphism modifies efficacy of botanical seed oil combination in asthma.” SpringerPlus 3 (1): 661. doi:10.1186/2193-1801-3-661. http://dx.doi.org/10.1186/2193-1801-3-661. | en |
dc.identifier.issn | 2193-1801 | en |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:13581258 | |
dc.description.abstract | Botanical seed oils reduce the generation of leukotrienes in patients with asthma. Our objective was to determine the efficacy of a botanical seed oil combination against airflow obstruction in asthma, and to determine the pharmacogenomic effect of the leukotriene C4 synthase (LTC4S) polymorphism A-444C. We conducted a randomized, double-blind, placebo-controlled, cross-over clinical trial in mild to moderate asthmatics to determine the change in FEV1 after 6 weeks of therapy with borage and echium seed oils versus corn oil placebo. We also examined the effect of the variant LTC4S -444C allele on the change in lung function. We did not identify a difference in FEV1 in the study cohort as a whole (n = 28), nor in the group of A homozygotes. In the C allele carriers (n = 9), FEV1 improved by 3% after treatment with borage and echium seed oils and declined by 4% after placebo corn oil (p = 0.02). All 9 C allele carriers demonstrated an improvement in their FEV1 on active treatment compared to placebo as compared to only 7 out of 19 A allele homozygotes (p = 0.007). We observed transient differences in ex vivo leukotriene generation from circulating basophils and granulocytes. We did not observe significant differences in urinary LTE4 levels. We conclude that compared to corn oil, a combination of borage and echium seed oils improves airflow obstruction in mild to moderate asthmatics who carry the variant allele in the LTC4S gene (A-444C). Botanical oil supplementation may have therapeutic potential in asthma if used in a personalized manner. Trial registration: This trial was registered at http://www.clinicaltrials.gov as NCT00806442. | en |
dc.language.iso | en_US | en |
dc.publisher | Springer International Publishing | en |
dc.relation.isversionof | doi:10.1186/2193-1801-3-661 | en |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4236308/pdf/ | en |
dash.license | LAA | en_US |
dc.subject | Asthma | en |
dc.subject | Borage oil | en |
dc.subject | Echium oil | en |
dc.subject | Leukotrienes | en |
dc.subject | LTC | en |
dc.title | LTC4 synthase polymorphism modifies efficacy of botanical seed oil combination in asthma | en |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en |
dc.relation.journal | SpringerPlus | en |
dash.depositing.author | Kazani, Shamsah | en_US |
dc.date.available | 2015-01-05T18:28:28Z | |
dc.identifier.doi | 10.1186/2193-1801-3-661 | * |
dash.authorsordered | false | |
dash.contributor.affiliated | Kazani, S | |
dash.contributor.affiliated | Boyce, Joshua | |
dash.contributor.affiliated | Israel, Elliot | |