dc.contributor.author | Rotstein, Benjamin H | |
dc.contributor.author | Liang, Steven | |
dc.contributor.author | Holland, Jason P | |
dc.contributor.author | Collier, Thomas L | |
dc.contributor.author | Hooker, Jacob M | |
dc.contributor.author | Wilson, Alan A. | |
dc.contributor.author | Vasdev, Neil | |
dc.date.accessioned | 2014-04-25T17:35:46Z | |
dc.date.issued | 2013 | |
dc.identifier.citation | Rotstein, Benjamin H., Steven H. Liang, Jason P. Holland, Thomas Lee Collier, Jacob M. Hooker, Alan A. Wilson, and Neil Vasdev. 2013. 11CO2 fixation: a renaissance in PET radiochemistry. Chemical Communications 49(50): 5621. | en_US |
dc.identifier.issn | 1359-7345 | en_US |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:12111436 | |
dc.description.abstract | Carbon-11 labelled carbon dioxide is the cyclotron-generated feedstock reagent for most positron emission tomography (PET) tracers using this radionuclide. Most carbon-11 labels, however, are installed using derivative reagents generated from [11C]CO2. In recent years, [11C]CO2 has seen a revival in applications for the direct incorporation of carbon-11 into functional groups such as ureas, carbamates, oxazolidinones, carboxylic acids, esters, and amides. This review summarizes classical [11C]CO2 fixation strategies using organometallic reagents and then focuses on newly developed methods that employ strong organic bases to reversibly capture [11C]CO2 into solution, thereby enabling highly functionalized labelled compounds to be prepared. Labelled compounds and radiopharmaceuticals that have been translated to the clinic are highlighted. | en_US |
dc.description.sponsorship | Chemistry and Chemical Biology | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Royal Society of Chemistry | en_US |
dc.relation.isversionof | doi:10.1039/c3cc42236d | en_US |
dash.license | LAA | |
dc.title | 11CO2 Fixation: A Renaissance in PET Radiochemistry | en_US |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en_US |
dc.relation.journal | Chemical Communications | en_US |
dash.depositing.author | Hooker, Jacob M | |
dc.date.available | 2014-04-25T17:35:46Z | |
dc.identifier.doi | 10.1039/c3cc42236d | * |
dash.contributor.affiliated | Rotstein, Benjamin H. | |
dash.contributor.affiliated | Collier, Thomas L | |
dash.contributor.affiliated | Holland, Jason P | |
dash.contributor.affiliated | Vasdev, Neil | |
dash.contributor.affiliated | Hooker, Jacob | |