Genome analysis reveals insights into physiology and longevity of the Brandt’s bat Myotis brandtii
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Seim, Inge
Fang, Xiaodong
Xiong, Zhiqiang
Lobanov, Alexey V.
Huang, Zhiyong
Feng, Yue
Zhu, Yabing
Gerashchenko, Maxim V.
Fan, Dingding
Hee Yim, Sun
Yao, Xiaoming
Xiong, Yingqi
Ma, Yong
Lyapunov, Andrey N.
Chen, Guanxing
Kulakova, Oksana I.
Sun, Yudong
Lee, Sang-Goo
Moskalev, Alexey A.
Zhang, Guojie
Krogh, Anders
Wang, Jun
Note: Order does not necessarily reflect citation order of authors.
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https://doi.org/10.1038/ncomms3212Metadata
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Seim, I., X. Fang, Z. Xiong, A. V. Lobanov, Z. Huang, S. Ma, Y. Feng, et al. 2013. “Genome analysis reveals insights into physiology and longevity of the Brandt’s bat Myotis brandtii.” Nature Communications 4 (1): 2212. doi:10.1038/ncomms3212. http://dx.doi.org/10.1038/ncomms3212.Abstract
Bats account for one-fifth of mammalian species, are the only mammals with powered flight, and are among the few animals that echolocate. The insect-eating Brandt’s bat (Myotis brandtii) is the longest-lived bat species known to date (lifespan exceeds 40 years) and, at 4–8 g adult body weight, is the most extreme mammal with regard to disparity between body mass and longevity. Here we report sequencing and analysis of the Brandt’s bat genome and transcriptome, which suggest adaptations consistent with echolocation and hibernation, as well as altered metabolism, reproduction and visual function. Unique sequence changes in growth hormone and insulin-like growth factor 1 receptors are also observed. The data suggest that an altered growth hormone/insulin-like growth factor 1 axis, which may be common to other long-lived bat species, together with adaptations such as hibernation and low reproductive rate, contribute to the exceptional lifespan of the Brandt’s bat.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753542/pdf/Terms of Use
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