Epigenetic Inheritance of a Cocaine Resistance Phenotype
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Author
Vassoler, Fair M.
White, Samantha L.
Schmidt, Heath D.
Pierce, R. Christopher
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https://doi.org/10.1038/nn.3280Metadata
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Vassoler, Fair M., Samantha L. White, Heath D. Schmidt, Ghazaleh Sadri-Vakili, and R. Christopher Pierce. 2012. “Epigenetic Inheritance of a Cocaine Resistance Phenotype.” Nature neuroscience 16 (1): 42-47. doi:10.1038/nn.3280. http://dx.doi.org/10.1038/nn.3280.Abstract
A heritable phenotype resulting from the self-administration of cocaine in rats was delineated. We observed delayed acquisition and reduced maintenance of cocaine self-administration in male, but not female, offspring of sires that self-administered cocaine. Brain-derived neurotrophic factor (BDNF) mRNA and protein were increased in the medial prefrontal cortex (mPFC) and there was an increased association of acetylated histone H3 with BDNF promoters only in the male offspring of cocaine-experienced sires. Administration of a BDNF receptor antagonist (the TrkB receptor antagonist ANA-12) reversed the diminished cocaine self-administration in male cocaine-sired rats. In addition, the association of acetylated histone H3 with BDNF promoters was increased in the sperm of sires that self-administered cocaine. Collectively, these findings indicate that voluntary paternal ingestion of cocaine results in epigenetic reprograming of the germline resulting in profound effects on mPFC gene expression and resistance to cocaine reinforcement in male offspring.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531046/pdf/Terms of Use
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