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The role of Complement C3 in the neurodevelopment of central nervous system
(2021-07-19)
Recent studies highlighted the role of complement C3 on neurogenesis, neuro-migration, and synaptic refinement, which are essential steps for normal brain development. Here we aimed to holistically reveal the role of ...
IMPROVING PATIENT SAFETY AND THE EVALUATION OF DISORDERS OF HYPERSOMNOLENCE IN THE SLEEP LAB
(2022-05-10)
Improved understanding of the complex physiology that underlies sleep disorders and new technologies applied to the field of sleep medicine require a re-calibration of patient care standards and new approaches to meeting ...
Optimal policy for attention-modulated decisions explains human fixation behavior
(2021-05-27)
Traditional accumulation-to-bound decision-making models assume that all choice options are processed with equal attention. In real-life decisions, however, humans alternate their visual fixation between individual items ...
Identification and Characterization of CD38+ Engulfing Periarterial Brain Border Macrophages
(2021-06-25)
Elimination of waste material in the central nervous system (CNS) plays a crucial role in maintaining an optimal environment for neuronal activity. Advances in the characterization of the glymphatic system and of ...
Small-Fiber Polyneuropathy: An Institutional Experience
(2021-06-23)
Small-fiber polyneuropathy (SFN) is an underdiagnosed disease characterized pathologically by the destruction of neurite fibers. Given the manifestations of this disease occur primarily in the skin, dermatologists play an ...
Validation of Clinical Prediction Models and Study of the Role of Modern Therapies Using Real-World Data in Spine Oncology
(2021-06-23)
With a rising incidence of cancer and improved life expectancy, more patients are being diagnosed and surviving longer with spinal metastases. Spinal metastases can significantly worsen patients' quality of life because ...
CLINICAL CHARACTERISTICS AND OUTCOMES OF CHILDREN WITH ACUTE CATASTROPHIC BRAIN INJURY: A 13-YEAR RETROSPECTIVE COHORT STUDY and HEART RATE CHANGE AS A POTENTIAL DIGITAL BIOMARKER OF BRAIN DEATH IN CRITICALLY ILL CHILDREN WITH ACUTE CATASTROPHIC BRAIN INJURY
(2022-05-10)
ABSTRACT (Manuscript 1)
Background & Purpose: To describe and analyze clinical characteristics and outcomes in children with acute catastrophic brain injury (CBI).
Methods: Single center, 13-year (2008-2020) retrospective ...
The Role of IL-17RA on Microglial Activation in Alzheimer’s Disease
(2021-07-19)
Microglia are brain resident immune cells which play a pivotal role in brain development, maintenance and disease. Previously, we have identified two major microglial phenotypes: the homeostatic microglia (M0) and ...
Approaches to improve the diagnosis and treatment of traumatic neuropathic pain
(2023-05-11)
"The most terrible of all tortures which a nerve wound may inflict.” Silas W. Mitchell, a neurologist during the American Civil War, stated in his book Injuries of Nerves and their Consequence. (1) One hundred and fifty ...
The Relationship between Depression, Stress-Related Neurobiology, and Incident Heart Failure: Understanding the Neurobiological Mechanisms Underlying Exercise as a Preventive Measure
(2023-05-11)
Background: Numerous evidence underscores the link between high metabolic activity in the brain related to stress (stress-related neural network activity, SNA) and increased risk of cardiovascular disease (CVD) events, ...