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Characterization of Immune Evasion Mechanisms of Breast Cancer Disseminated Cells in the Lung
(2021-07-19)
Despite recent advances in cancer immunotherapies, many patients still die from metastasis. Metastases arise from cells that escape the primary tumor and disseminate to distant organs. A more comprehensive understanding ...
Investigating the Impact of Chemotherapy Exposure on Peripheral Immune Responses for Patients with Ovarian Cancer
(2021-07-19)
The current treatment of epithelial ovarian cancer (EOC) is based on surgical tumor debulking and platin-based chemotherapy. Neoadjuvant chemotherapy is used for initial tumor shrinkage before debulking surgery, but ...
Murine Airway Brush Cell Functions in Chronic Type II Inflammation
(2021-07-19)
Type-II (T2) inflammatory airway diseases are characterized by airway epithelial damage, epithelial remodeling, and goblet cell metaplasia, in addition to the immune cell influx. Brush cells (BrCs) are specialized chemosensory ...
lncRNA CRNDE204 regulates erythropoiesis and myelopoiesis by binding to PUS1
(2021-07-19)
Hematopoiesis is a crucial process that produces all cells within the hematopoietic system. Mutations in genes that disrupt normal hematopoiesis can cause bone marrow failure disorders ranging from myelodysplastic syndromes ...
Contributions of BCL3 to Humoral Immunity
(2021-07-19)
The inhibitors of NF-B (IB) are regulators of NF-B signaling that typically sequester NF-B subunits in the cytosol, thereby restraining the inflammatory response. Unlike other IB proteins, the atypical IB proteins, ...
Differential Abundant Cell Population Analysis in COVID-19PBMC and Immune Checkpoint Blockade Single Cell RNASequencing Data
(2021-06-25)
Understanding immunological changes underlying tumors and disease microenvironments of other disorders, such as SARS-COV-2, has been challenging because it involves measuring genomic, epigenetic, and molecular changes in ...
SARS-CoV-2 infects blood monocytes to activate NLRP3 and AIM2 inflammasomes, pyroptosis and cytokine release
(2021-06-25)
The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has infected over 100 million people and caused more than 2 million deaths worldwide. Although most infected people develop mild ...
In vitro and in vivo studies of VISTA: a B7 family immune checkpoint receptor
(2021-06-25)
Immunotherapy has become an established pillar of cancer treatment, in large part owing to the success of blocking the programmed cell death protein 1 (PD-1)/ programmed death-ligand 1 (PD- L1) immune checkpoint pathway. ...
Examination of brain tumor-associated astrocytes at single-cell resolution
(2021-07-19)
Astrocytes are multifunctional cells of the central nervous system (CNS), are intimately linked into the immune modulatory processes that govern homeostasis and neuroinflammation, and display significant functional ...
Characterising Long Non-Coding RNAs (lncRNAs) Associated with a Protective Type 1 Interferon (IFN) Gene Signature in Tumour and Immune cells
(2021-07-19)
Type 1 interferons have emerged as critical regulators of cancer immunity. By inducing the transcription of interferon-stimulated genes (ISGs), these cytokines can directly inhibit tumour proliferation and mediate apoptosis, ...