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Examination of brain tumor-associated astrocytes at single-cell resolution
(2021-07-19)
Astrocytes are multifunctional cells of the central nervous system (CNS), are intimately linked into the immune modulatory processes that govern homeostasis and neuroinflammation, and display significant functional ...
The Role of IL-17RA on Microglial Activation in Alzheimer’s Disease
(2021-07-19)
Microglia are brain resident immune cells which play a pivotal role in brain development, maintenance and disease. Previously, we have identified two major microglial phenotypes: the homeostatic microglia (M0) and ...
Single-cell immune analysis of chronic GVHD after hematopoietic stem cell transplantation
(2023-05-10)
Patients with life-threatening hematologic malignancies often receive hematopoietic stem cell transplants as a treatment of last resort. Unfortunately, allogeneic transplant patients regularly develop graft-versus-host ...
Change, Source, and Effect of GDF11 in Mouse Spleen
(2023-05-10)
Growth differentiation factor 11 (GDF11) is a secreted ligand of the transforming growth factor-β (TGF-β) superfamily of proteins and regulates gene expression through AKT-MTORC1 pathway. GDF11 has been proposed as a ...
Reprogramming of airway mononuclear phagocytes in response to type 2 inflammation
(2023-05-10)
There is a global epidemic of asthma which affects all age groups and leads to significant public health challenges. Allergy-associated asthma is the most common phenotype; thus, it is important to understand the mechanistic ...
Heterogeneity of B cell helper T cells in murine pristane-induced lupus
(2023-05-10)
T follicular helper (Tfh) cells are considered the major T cells capable of stimulating B cells responses, and these cells can promote germinal center responses and autoantibody production in autoimmune diseases. However, ...
Understanding the role of T cells in stress-induced hair loss.
(2023-05-10)
Stress causes physiological changes that have long been conjectured to include hair loss. However, the scientific understanding behind stress induced hair loss remains unclear. Alopecia areata (AA) is a broad term for a ...
SARS-CoV-2 targets NKG2D ligands to evade natural killer cell-mediated immunity
(2023-05-10)
Severe acute respiratory syndrome (SARS-CoV-2) is responsible for the ongoing global COVID-19 pandemic. This virus continues to drive research to develop vaccines and therapeutics as well as to characterize host immune ...
Therapeutic Impact of Homologous Recombination Repair (HRR) or Nucleotide Excision Repair (NER) Deficiency Pertaining to Antibody Drug Conjugate (ADC) Payloads in Urothelial Cancer
(2024-04-26)
Background:
Approximately 10% of urothelial cancer (UC) patients have defects in the Nucleotide Excision Repair (NER) pathway and at least another 10% have defects in the Homologous Recombination Repair (HRR) pathway. ...