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FACIOSCAPULOHUMERAL MUSCULAR DYSTROPHY: CLINICAL AND GENETIC DIAGNOSIS
(2022-05-10)
Background: Facioscapulohumeral muscular myodystrophy (FSHD) is a hereditary myodystrophy typically affecting skeletal muscles of the facial muscles, shoulder girdles, and upper arms. The clinical course of FSHD is highly ...
Differential Abundant Cell Population Analysis in COVID-19PBMC and Immune Checkpoint Blockade Single Cell RNASequencing Data
(2021-06-25)
Understanding immunological changes underlying tumors and disease microenvironments of other disorders, such as SARS-COV-2, has been challenging because it involves measuring genomic, epigenetic, and molecular changes in ...
Examination of brain tumor-associated astrocytes at single-cell resolution
(2021-07-19)
Astrocytes are multifunctional cells of the central nervous system (CNS), are intimately linked into the immune modulatory processes that govern homeostasis and neuroinflammation, and display significant functional ...
The role of Complement C3 in the neurodevelopment of central nervous system
(2021-07-19)
Recent studies highlighted the role of complement C3 on neurogenesis, neuro-migration, and synaptic refinement, which are essential steps for normal brain development. Here we aimed to holistically reveal the role of ...
COMPREHENSIVE FUNCTIONAL AND MOLECULAR PROFILING AND INTEGRATIVE ANALYSES OF PRIMARY AND METASTATIC TRIPLE NEGATIVE BREAST CANCERS
(2022-05-10)
In summary, the first project was focused on investigating inter/intra-tumor epigenetic heterogeneity in TNBCs and its functional relevance. We characterized the heterogeneity of TNBCs, by combining functional and molecular ...
CLINICAL CHARACTERISTICS AND OUTCOMES OF CHILDREN WITH ACUTE CATASTROPHIC BRAIN INJURY: A 13-YEAR RETROSPECTIVE COHORT STUDY and HEART RATE CHANGE AS A POTENTIAL DIGITAL BIOMARKER OF BRAIN DEATH IN CRITICALLY ILL CHILDREN WITH ACUTE CATASTROPHIC BRAIN INJURY
(2022-05-10)
ABSTRACT (Manuscript 1)
Background & Purpose: To describe and analyze clinical characteristics and outcomes in children with acute catastrophic brain injury (CBI).
Methods: Single center, 13-year (2008-2020) retrospective ...
IMMUNOGENICITY OF EPIGRAPH ANTIGENS IN VACCINATION AGAINST SARS-COV-2 IN MICE
(2023-05-10)
The ongoing COVID-19 pandemic continues to rapidly evolve, remaining one of the leading public health concerns worldwide and making the development of a safe and effective vaccine a global priority. Most currently-available ...
Single-cell immune analysis of chronic GVHD after hematopoietic stem cell transplantation
(2023-05-10)
Patients with life-threatening hematologic malignancies often receive hematopoietic stem cell transplants as a treatment of last resort. Unfortunately, allogeneic transplant patients regularly develop graft-versus-host ...
EpiGraph Pan-coronavirus Vaccine: An Immunogenicity Study of Computationally-Predicted Antigen Vaccine in Mice
(2023-05-10)
In late 2019, a highly transmissible and pathogenic RNA virus termed Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in the Hubei province of China causing the coronavirus disease (COVID-19), which ...
Categorizing the dispersion of open chromatin usage patterns of Treg related genes using an variational autoencoder based algorithm
(2023-05-10)
Cellular programs are controlled by the coordinated interactions between transcription factors (TF) and cis-regulatory genomic sequences, including enhancer elements which can be far from the TF they regulate. This enables ...