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Adaptive Expertise in Plastic Surgery: The Plastic Surgeon Experience of Developing, Maintaining and Teaching Adaptive Expertise
(2024-01-17)
Background: Plastic surgery is a surgical field defined not by a particular anatomical domain, age group, nor pathology. Instead, it is characterized by problem-solving and innovation. Adaptive expertise, described initially ...
PIGMENTED SKIN LESIONS IN CHILDREN: CONGENITAL MELANOCYTIC NEVUS, PEDIATRIC LONGITUDINAL MELANONYCHIA, AND PEDIATRIC MELANOMA
(2024-04-26)
Background: Considering childhood is a prime period for nevogenesis and given the ectodermal origin of melanocytes and neural tissues, congenital or early-onset nevi might be associated with neurological and developmental ...
Therapeutic Impact of Homologous Recombination Repair (HRR) or Nucleotide Excision Repair (NER) Deficiency Pertaining to Antibody Drug Conjugate (ADC) Payloads in Urothelial Cancer
(2024-04-26)
Background:
Approximately 10% of urothelial cancer (UC) patients have defects in the Nucleotide Excision Repair (NER) pathway and at least another 10% have defects in the Homologous Recombination Repair (HRR) pathway. ...
Prediabetes and Gout Risk: The Role of Metformin Use and Longitudinal Serum Urate Analysis
(2024-04-26)
Background:
Despite the strong association between gout and prediabetes, the role of antidiabetic medications in managing gout among individuals with prediabetes remains uncertain. We estimated the incidence of gout and ...
Non-cutaneous infections in patients with hidradenitis suppurativa
(2024-04-29)
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disorder that typically begins after puberty, primarily affecting young adults. It is associated with a wide array of comorbidities, including inflammatory ...
Association of objective measures of volume status with blood pressure, cardiac structure, and cardiac function among patients receiving maintenance hemodialysis
(2024-04-30)
Background Intradialytic hypertension, defined as an increase in BP from pre- to post-hemodialysis (HD), affects
5%–15% of patients receiving maintenance HD and is associated with cardiovascular and all-cause mortality.
...
Carbamylation in Chronic Kidney Disease: Comparative Biomarker Analysis and Implications for Cardiovascular Disease
(2024-05-01)
As the global incidence of chronic kidney disease (CKD) escalates, there is a pressing need to better understand its pathophysiology and associated morbidity. A focal point of such research is carbamylation, a post-translational ...
Unraveling Genetic and Molecular Mechanisms of Trastuzumab Resistance in Cancer and Therapy-Associated Polyposis: Insights into Pathogenesis and Therapeutic Implications
(2024-05-03)
Background
Intratumoral heterogeneity (ITH) of HER2 amplifications, and other oncogenic driver alterations are common in HER2+ GEA. However, their importance in predicting response to trastuzumab based therapy in these ...
Evaluating the Impact of HCT-CI-Age Score and Pre-Transplant Social Determinants of Health on Non-Relapse Mortality in a Modern Cohort with Post-Transplant Cyclophosphamide-Based GvHD Prophylaxis
(2024-05-02)
Allogenic hematopoietic transplantation (alloHCT) is the most promising curative treatment in AML/MDS, however the mortality after alloHCT due to nonrelapse mortality (NRM) was 22.3%(1). One of the causes of mortality after ...
FINDING NEW INTERVENTIONS TO SLOW KIDNEY FUNCTION DECLINE IN DIABETES
(2024-05-03)
The focus of my research is on preventing kidney function loss in people with diabetes. Diabetic kidney disease (DKD) is a major cause of increased morbidity and mortality among persons with diabetes, and the estimated ...