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Dissecting The Mechanisms of Transitional B Cell Tolerance
(2023-05-10)
The study of B cell tolerance has remained elusive for many years. However, patients with primary immunodeficiencies resulting from monogenic causes who present with autoimmune manifestations can be studied to elucidate ...
Investigation on the Immunogenicity of Neuraminidase and Optimization of Antigen Display for Influenza Vaccines
(2023-05-10)
Influenza viruses have co-existed with humans for centuries and continue, to this day, to cause significant health and economic burdens during yearly seasonal epidemics and especially during unpredictable pandemic years. ...
IMMUNOGENICITY OF EPIGRAPH ANTIGENS IN VACCINATION AGAINST SARS-COV-2 IN MICE
(2023-05-10)
The ongoing COVID-19 pandemic continues to rapidly evolve, remaining one of the leading public health concerns worldwide and making the development of a safe and effective vaccine a global priority. Most currently-available ...
DNA Methylation And In Vitro Induction of Cytotoxic CD4+ T-cells
(2023-05-10)
Cytotoxic CD4+ T-cells (CD4+ CTLs) have been observed in various disease contexts and more prevalently in chronic inflammatory diseases. Ranging from autoimmunity to severe acute and chronic viral infection to cancers, ...
Reversing tumor immunoediting by inhibiting DNA methylation
(2023-05-10)
Cancer cells use DNA hypermethylation to downregulate tumor suppressor genes and important immune-related genes to escape immune surveillance. However, not much is known about which genes are modified by DNA methylation ...
Peripheral T helper Cells in a Murine Chronic Inflammation Model
(2023-05-10)
A germinal center forms in secondary lymphoid organs during a T-cell dependent humoral immune response and yields high-affinity antibodies against incoming pathogens. Within the germinal centers are follicular helper T ...
The Effect of AhR Agonist Tapinarof on Dendritic Cells and T cells In Vitro
(2023-05-10)
Psoriasis is a chronic inflammatory skin condition mediated by a dysregulated immune system. Patients with psoriasis not only deal with plaques on their skin, they also have an increased risk of developing comorbidities ...
Characterizing the role of ETV6 in lymphoid development and B-cell acute lymphoblastic leukemia predisposition
(2023-05-10)
B cell acute lymphoblastic leukemia (ALL) is the most common form of pediatric
cancer and one of the leading causes of death in children, characterized by clonal
expansion of malignant lymphoid progenitors. While recent ...
AREG and IFNG Define Subsets of γδ T Cells with Distinct Functional Properties in Human Cancer
(2023-05-10)
γδ T cells are a subset of innate T cells. They activate in minutes - rather than days - after stimulus and play a role in immune surveillance and anti-tumor responses. In general, the presence of γδ T cells in tumors is ...
Identifying Long Non-Coding RNAs Associated with a Protective Type I Interferon Signature in Melanoma
(2023-05-10)
Long non-coding RNAs (lncRNAs) have emerged as a new class of regulators of type I interferon (IFN) signaling and can potentially serve as therapeutic targets.1 In this study, we identified lncRNAs that are associated with ...