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Patient-Derived Organotypic Tumor Spheroids Facilitate Precision Medicine Advances in Therapeutic Screening for Malignant Pleural Mesothelioma
(2019-05-06)
Malignant pleural mesothelioma (MPM) is an aggressive cancer with limited curative treatment, common tumor recurrence, and poor prognosis. Given the fatal nature of this disease and limited effectiveness of conventional ...
Ambient Temperature and Sudden Infant Death Syndrome in the United States
(2019-05-06)
Background: Sudden infant death syndrome (SIDS) is a leading cause of infant mortality in the United States. While thermal stress is implicated in many risk factors for SIDS, the association between ambient temperature and ...
Rationale for Combination Chemoradiation and Immune Checkpoint Blockade in Head and Neck Malignancies
(2019-05-06)
Immune checkpoint inhibitors (ICPi) have demonstrated activity and survival benefit in advanced head and neck squamous cell carcinomas (HNSCC), but many patients still do not respond. It is also uncertain whether other ...
Chemogenetic Approaches to Studying Cardiovascular Redox Signaling in Vivo
(2019-05-06)
Oxidant signaling plays many sometimes seemingly opposite roles in both mammalian physiology and disease. Reactive oxygen species (ROS) such as hydrogen peroxide (H2O2) generated by cellular respiration and specialized ...
a Practical Guide to Ethical Decision-Making Regarding Drug Coverage for Rare Diseases: Case Study of Nusinersen Therapy for Spinal Muscular Atrophy
(2019-05-06)
Nusinersen for the treatment of Spinal Muscular Atrophy was among the first definitive treatments for neurodegenerative conditions to come to market as of 2016. The drug’s rapid U.S. governmental approval came on the heels ...
IL-33/Regulatory T Cell Axis Triggers the Development of a Tumor-Promoting Immune Environment in Chronic Inflammation
(2019-05-06)
Chronic inflammation’s tumor-promoting potential is well-recognized; however, the mechanism underlying the development of this immune environment is unknown. In contrast to anti-tumor immunity in acute allergic contact ...
Preventing Opioid Misuse and Potential Abuse Among Adolescents in Massachusetts Through a Parent Education Program
(2019-08-15)
EXECUTIVE SUMMARY
Purpose of This Report
Over the past 15 years, families, communities, and individuals across the United States have been tragically affected by the opioid epidemic with more than 130 people dying daily ...
Skeletal Fragility in Type 2 Diabetes Mellitus: Bone Mechanical Properties, Microarchitecture, and Advanced Glycation End-Products in the Proximal Femur
(2019-05-06)
Osteoporosis is a metabolic bone disorder characterized by depleted bone mass, remodeling of microarchitecture, and an increased incidence of fractures. Predominantly diagnosed through a measurement of low bone mineral ...
Amygdalar Activity Measured Using FDG-PET/CT at Head and Neck Cancer Staging Independently Predicts Survival and Cardiovascular Outcomes: A Retrospective Cohort Study
(2019-06-03)
Background
Chronic stress associates with higher mortality among individuals with cancer; however, the mechanisms underlying this association remain incompletely understood. Quantification of amygdalar metabolic activity ...
Characterization of the T Cell Repertoire Following Personalized Neoantigen-Based Vaccination in Patients with Melanoma
(2019-05-06)
Neoantigens represent a class of tumor specific antigens that are encoded by somatic mutations which arise in cancer cells. Neoantigens are particularly attractive for the development of personalized cancer vaccines as ...