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Measuring Psychosocial Adversity as a Neurodevelopmental Risk Factor: Development & Validation of the Childhood Psychosocial Adversity Questionnaire–Bangladesh (CPAQ-B)
(2018-05-15)
BACKGROUND: Research examining effects of psychosocial adversities on child neurocognitive development has occurred largely in high-income countries. A key barrier to global extension of this work has been a lack of ...
Evaluation of the Efficacy and Side-Effects of Androgen Deprivation Therapy in Nonmetastatic Prostate Cancer
(2018-05-15)
Background
While the addition of androgen deprivation therapy (ADT) to external beam radiation therapy (EBRT) is known to improve overall survival for patients with high-risk prostate cancer (Gleason score of 8-10, ...
Social Encoding in the Medial Prefrontal Cortex
(2018-05-15)
Social dysfunction is among the most prominent features of autism spectrum disorder (ASD). Despite a growing understanding of its genetic and micro-anatomic underpinnings, little is known about how ASD influences the ...
Postoperative Outcomes in Patients with Do-not-resuscitate (DNR) Orders undergoing Elective Surgery
(2018-05-15)
Background: Do-Not-Resuscitate (DNR) is a medical order against the use of cardiopulmonary resuscitation. While it does not preclude surgery, DNR status has been shown to be independently associated with worse surgical ...
Heart Failure in Patients With Stable Atherosclerosis: A Post Hoc Analysis of the TRA 2°P-TIMI 50 Trial
(2018-05-15)
Background: Heart failure is a growing public health burden and a morbid complication of atherosclerotic cardiovascular disease. Antiplatelet therapy is commonly used for the
secondary prevention of atherothrombotic ...
Functional Interactions in the Hematopoietic Stem Cell Niche: Stem Cells, Endothelial Cells, and Macrophages
(2018-05-15)
The hematopoietic stem cell (HSC) niche is a specialized environment that supports the maintenance and regulation of hematopoietic stem and progenitor cells (HSPCs). The various cell types that comprise the niche and the ...
Nanoanalytical Analysis of Bisphosphonate-Induced Alterations of Microcalcifications Using a 3D Hydrogel Platform
(2018-05-15)
Vascular calcification predicts atherosclerotic plaque rupture and cardiovascular events. Retrospective studies of women taking bisphosphonates (BiPs), a proposed therapy for vascular calcification, showed that BiPs ...
Nature Versus Nurture: The Impact of Nativity and Site of Treatment on Survival for Gastric Cancer
(2018-05-15)
Purpose: The prognosis of gastric cancer patients is substantially better in Asia than in the West. Genetic, environmental, and treatment factors have all been implicated. We sought to explore the extent to which the place ...
Assessing the Effect of Epigenetic Dysregulation on Oncogenesis and Immunocompetence in a Mouse Model
(2018-05-15)
While there is a clear link between increasing mammalian age and alteration in baseline gene expression in somatic cells, the causality of these changes, how they affect the aging process itself, and their effect on ...
Neural Mechanisms of Mechanosensation Within the Body
(2018-05-15)
The ability to detect mechanical forces plays a critical role in organism behavior and physiology. One of the fundamental means by which we interact with our environment is through touch, which includes the ability to sense ...