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Quantitative Imaging Analysis of Non-Small Cell Lung Cancer
(2016-05-17)
Quantitative imaging is a rapidly growing area of interest within the field of bioinformatics and biomarker discovery. Due to the routine nature of medical imaging, there is an abundance of high-quality imaging linked to ...
Characterizing EEG Brain States During General Anesthesia in Children: Insights for Improved Brain Monitoring
(2016-05-17)
Current brain monitors in clinical anesthesia use electroencephalography (EEG) based single indices (patient state indices, PSIs) as a biomarker for level of unconsciousness. These values range from zero (isoelectric) to ...
An Exploration of Risk Stratification for Active Surveillance and Androgen Deprivation Therapy Side Effects for Prostate Cancer Utilizing Data From the Surveillance, Epidemiology, and End Results Database
(2016-05-17)
Part 1: Occult high-risk disease in clinically low-risk prostate cancer patients: Incidence and clinical predictors from SEER data
Objective: First, to determine the incidence of pathologic upgrading and upstaging for ...
The Ethics of Electronically Monitoring Adherence to Antiretroviral Therapy: Theoretical Considerations and Empiric Findings
(2016-05-17)
Research Problem: Many electronic adherence monitors (EAMs) exist to track medication adherence, but despite attention in the popular press and expanding use of these devices, the ethics of using EAMs are largely unexplored. ...
Evolutionary Diversity of the Mitochondrial Calcium Uniporter and Its Contribution to Cardiac and Vascular Homeostasis
(2016-05-17)
Altered cardiac energetics and calcium handling are characteristic features of cardiovascular disease. Mitochondria play a significant role in both cellular energy generation and calcium homeostasis and may be a key ...
Integrated Molecular Epidemiology of Colorectal Cancer: An Exploration of Chronic Inflammation and the Gut Microbiome
(2016-05-17)
Background: Colorectal cancer (CRC) is a heterogeneous disease, arising from a complex environment of host inflammation and gut microbes. We investigated whether the novel circulating inflammatory molecule, Macrophage ...
Clinical Evidence Supporting Pharmacogenomic Biomarker Testing Provided in US Food and Drug Administration Drug Labels
(2016-05-17)
Background: Genetic biomarkers that predict a drug’s efficacy or likelihood of toxicity are assuming increasingly important roles in the personalization of pharmacotherapy, but there is concern that there may be insufficient ...
Perspectives on Elective Abortion Among Palestinian Women: Religion, Culture and Access in the Occupied Palestinian Territories
(2016-05-17)
Background: Termination of pregnancy remains a highly debated topic in women’s health in the Middle East and specifically in the occupied Palestinian territories (OPT), where it is illegal in most cases. To better understand ...
Combined Effect of Histone Acetylation and Acetyl Mark Readers on Radiation Sensitivity
(2016-05-17)
We are interested in studying potential drugs that have the ability to make tumors more sensitive to radiation. There has been much interest in examining the effect of modulation to chromatin structure on the DNA damage ...
Concentric Tube Robotics: Non-Linear Trajectories for Epilepsy Surgery
(2016-05-17)
Recurrent and unprovoked epilepsy seizures affect more than 50 million people worldwide. Despite advances in antiepileptic drugs, more than 30% of patients continue to demonstrate abnormal neuronal activity; at present, ...