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A Critical Period for Functional Motor Recovery After Peripheral Nerve Injury in the Mouse
(2014-07-07)
Repair of peripheral nerve injury often results in poor functional motor recovery. This deficit has previously been attributed to the failure of axons to regenerate into the muscle. However, we have recently reported that ...
The Role of SPARC in Aqueous Humor Outflow and TGFß2-mediated Ocular Hypertension in a Murine Model
(2014-07-07)
Glaucoma is the leading cause of irreversible blindness worldwide, and is a major cause of blindness in the United States. It affects approximately 5% of Caucasians and 10% of African- Americans over the age of 60 years. ...
Technology Adoption in the United States: The Impact of Hospital Market Competition
(2014-07-07)
Objectives: Technological innovation in medicine is a significant driver of healthcare spending growth in the United States. Factors driving adoption and utilization of new technology is poorly understood, however market ...
The Emotional Intelligence of Resident Physicians
(2014-07-07)
Since academic literature indicates that emotional intelligence (EI) is tied to work performance, there is increasing interest in understanding physician EI. We studied the EI of resident physicians in surgery, pediatric, ...
PROPHYLACTIC MASTECTOMIES: OCCULT HISTOLOGY AND FISCAL IMPACTS OF SURVEILLANCE VS. SURGERY
(2014-07-07)
Introduction:
During the last decade, our institution saw a 260% increase in bilateral breast reconstruction cases, consistent with national trends. We reported a drop in average age of prophylactic mastectomy from 57 to ...
DEFINITIVE PRIMARY THERAPY IN PATIENTS PRESENTING WITH OLIGOMETASTATIC NON-SMALL CELL LUNG CANCER (NSCLC)
(2014-07-07)
Background: Although palliative chemotherapy is the standard of care for patients diagnosed with stage IV NSCLC, patients with a small metastatic burden, “oligometastatic” disease, may benefit from definitive local therapy. ...
Modulation of Pain with Transcranial Direct Current Stimulation and Diffuse Noxious Inhibitory Controls
(2014-07-07)
Background: While pain is essential for physiological functioning, chronic or pathologic pain is responsible for a major burden of disease in society. Novel approaches to treating acute and chronic pain have employed ...
Identifying Targetable Liabilities in Ewing Sarcoma
(2014-07-07)
Background: Despite multi-modality therapy, the majority of patients with metastatic or recurrent Ewing sarcoma (ES), the second most common pediatric bone malignancy, will die of their disease. ES tumors express aberrantly ...
Imaging of PARP1/2-Overexpressing Cancers with Novel AZD2281-Derived Probes
(2014-07-07)
Poly(ADP-ribose)polymerase-1 and -2 (PARP1/2) are nuclear proteins involved in DNA repair. Tumors with defects in homologous recombination, including BRCA1- and BRCA2-deficient cancers, have been shown to be sensitive to ...
Optimizing siRNA Efficacy through Alteration in the Target Cell-Adhesion Substrate Interaction
(2014-07-07)
Short interfering RNA (siRNA) is a class of nucleotide drugs with a profound potential to improve patient health through its ability to silence the expression of specific genes at the post-transcriptional level. However, ...