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Integration of common and rare genetic variation across complex traits and neuropsychiatric disorders
(2022-09-08)
Research into the genetic basis of human disease has progressed rapidly over the past 20 years. Genome-wide association studies have identified thousands of links between common variants and phenotypic outcomes. More ...
Methods for inferring dynamical systems from biological data with applications to HIV latency and genetic drivers of aging
(2022-11-23)
This thesis focuses on developing advanced methods to infer the dynamical systems governing biological processes. Over the past century, techniques to describe the nonlinear dynamics of interacting systems in precise ...
Essays in Decision Theory
(2021-04-02)
This dissertation comprises three independent chapters that span topics in decision theory, including ethical decision-making, learning from others, and anticipatory emotions.
In Chapter 1, I model decision-making ...
Investigating the Mechanism of Non-Enzymatic RNA Replication
(2021-07-12)
Before life became confoundingly complex it must have been simpler. In modern biology, polymerase enzymes leverage the molecular recognition of nucleic acids through Watson-Crick base pairs to efficiently synthesize genomic ...
Heresies: On an Armenian prayer to the sun
(BRILL, 2020-02-03)
The Interrupted Feast
(Brill, 2020-02-03)
Topics in International Macroeconomics and Econometrics
(2021-01-20)
This dissertation is composed of three essays, two in international macroeconomics and one in climate econometrics. The former center on two main features of emerging market economies: financial dollarization of private ...
The role of RNA splicing factors in the regulation of longevity
(2021-11-16)
Geroscience aims to target the aging process to extend healthspan. However, the efficacy of pro- longevity interventions is highly heterogeneous, limiting their translational potential. In my dissertation research, I ...
Advancing precision genome and transcriptome engineering
(2022-11-23)
The cells within all living organisms contain genomic DNA that encodes the information for their structure, function, and capabilities. According to the central dogma of biology, this DNA is transcribed to RNA and this RNA ...
Revaluing Viability: Science and Legumes in Indian Agriculture
(2022-05-12)
In the mid-twentieth century, Indian scientists collected wild relatives of the pigeon pea and chickpea, piecing together their traits and useful qualities. Alongside this research and knowledge production, hybrids were ...