Browsing by Keyword "zebrafish"
Now showing items 1-20 of 36
-
Adaptive Locomotor Behavior in Larval Zebrafish
(Frontiers Media SA, 2011)In this study we report that larval zebrafish display adaptive locomotor output that can be driven by unexpected visual feedback. We develop a new assay that addresses visuomotor integration in restrained larval zebrafish. ... -
Advancing the Science of Developmental Neurotoxicity (DNT): Testing for Better Safety Evaluation
(ALTEX Edition, 2012) -
Angiopoietin-like proteins stimulate HSPC development through interaction with notch receptor signaling
(eLife Sciences Publications, Ltd, 2015)Angiopoietin-like proteins (angptls) are capable of ex vivo expansion of mouse and human hematopoietic stem and progenitor cells (HSPCs). Despite this intriguing ability, their mechanism is unknown. In this study, we show ... -
BMP signaling modulation attenuates cerebral arteriovenous malformation formation in a vertebrate model
(Nature Publishing Group, 2014)Cerebral arteriovenous malformations (AVMs) are vascular anomalies that carry a high risk of stroke and death. To test potential AVM therapies, a reverse genetics approach was used to model AVMs in zebrafish. Antisense ... -
Caudal Transcription Factors in Hematopoietic Development
(2013-02-12)During embryogenesis, hematopoietic cells arise from the lateral plate mesoderm (LPM) following gastrulation. The transcriptional program required for this LPM to blood switch is not fully understood. Previous work on a ... -
Challenging zebrafish escape responses by increasing water viscosity
(The Company of Biologists, 2012)Escape responses of fishes have long been studied as a model locomotor behavior in which hypothesized maximal or nearmaximal muscle power output is used to generate rapid body bending. In this paper we present the results ... -
Chemical Genetics of Hematopoietic Stem Cell Transplantation
(2012-09-18)Hematopoietic stem and progenitor cells (HSPCs) repopulate the blood system upon transplantation. A large-scale genetic approach to understand the factors that participate in successful engraftment has not been undertaken. ... -
Chromatin-Modifying Factors in Zebrafish Models of Rhabdomyosarcoma and Hematopoiesis
(2012-12-20)Epigenetics, or the reversible and heritable marks of gene regulation not including DNA sequence, encompasses modifications on both the DNA and histones and is as important as the DNA sequence itself. Gene transcription, ... -
Control of Turning Behaviors by Spinal Projection Neurons in the Larval Zebrafish
(2012-09-17)This thesis aims to examine how hindbrain spinal projection neurons (SPNs), namely RoV3, MiV1 and MiV2 control tail undulations during turning behaviors. I find that phototaxic turns differ from forward swims by an increased ... -
Decision Making, Behavioral Development and Fine Motor Control In Larval Zebrafish
(2023-05-02)All organisms need to make decisions after processing sensory inputs. The drift-diffusion model accurately captures average responses observed in the optomotor response of larval zebrafish but fails to capture the structure ... -
Discovering novel neuroactive drugs through high-throughput behavior-based chemical screening in the zebrafish
(Frontiers Media S.A., 2014)Most neuroactive drugs were discovered through unexpected behavioral observations. Systematic behavioral screening is inefficient in most model organisms. But, automated technologies are enabling a new phase of discovery-based ... -
Epigenetic Regulation of Hematopoiesis in Zebrafish
(2012-11-02)The initiation of the hematopoietic program is orchestrated by key transcription factors that recruit chromatin regulators in order to activate or inhibit blood target gene expression. To generate a complete compendium of ... -
Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis
(eLife Sciences Publications, Ltd, 2015)NCOA4 is a selective cargo receptor for the autophagic turnover of ferritin, a process critical for regulation of intracellular iron bioavailability. However, how ferritinophagy flux is controlled and the roles of NCOA4 ... -
The function of the Heg-CCM pathway in zebrafish heart development
(2013-10-08)The Heart of glass-Cerebral Cavernous Malformation (Heg-CCM) pathway is essential for heart development in zebrafish and mouse. In zebrafish, mutants for the Heg-CCM genes ccm1, ccm2, and heg exhibit an extreme dilation ... -
The habenular nuclei: a conserved asymmetric relay station in the vertebrate brain
(The Royal Society, 2009)The dorsal diencephalon, or epithalamus, contains the bilaterally paired habenular nuclei and the pineal complex. The habenulae form part of the dorsal diencephalic conduction (DDC) system, a highly conserved pathway found ... -
Hematopoietic Stem Cells, Hematopoiesis and Disease: Lessons from the Zebrafish Model
(BioMed Central, 2011)The zebrafish model is rapidly gaining prominence in the study of development, hematopoiesis, and disease. The zebrafish provides distinct advantages over other vertebrate models during early embryonic development by ... -
Inhibitors of Neutrophil Recruitment Identified Using Transgenic Zebrafish to Screen a Natural Product Library
(The Company of Biologists, 2013)Cell migration is fundamental to the inflammatory response, but uncontrolled cell migration and excess recruitment of neutrophils and other leukocytes can cause damage to the tissue. Here we describe the use of an in vivo ... -
Mlck1a Is Expressed in Zebrafish Thrombocytes and Is an Essential Component of Thrombus Formation
(Wiley-Blackwell, 2009)Background: We have used the advantages of the zebrafish model system to demonstrate which of the vertebrate Myosin Light Chain Kinase (MLCK) genes is expressed in thrombocytes and important for thrombus formation. Methods ... -
Monitoring Neural Activity with Bioluminescence during Natural Behavior
(Nature Publishing Group, 2010)Existing techniques for monitoring neural activity in awake, freely behaving vertebrates are invasive and difficult to target to genetically identified neurons. We used bioluminescence to non-invasively monitor the activity ... -
Navigational strategies underlying phototaxis in larval zebrafish
(Frontiers Media S.A., 2014)Understanding how the brain transforms sensory input into complex behavior is a fundamental question in systems neuroscience. Using larval zebrafish, we study the temporal component of phototaxis, which is defined as ...