Browsing by Keyword "yeast and fungi"

Now showing items 1-5 of 5

    • Antifungal Chemical Compounds Identified Using a C. elegans Pathogenicity Assay 

      Breger, Julia; Fuchs, Beth Burgwyn; Aperis, George; Moy, Terence I; Ausubel, Frederick M.; Mylonakis, Eleftherios; Cormack, Brendan P (Public Library of Science, 2007)
      There is an urgent need for the development of new antifungal agents. A facile in vivo model that evaluates libraries of chemical compounds could solve some of the main obstacles in current antifungal discovery. We show ...

    • Heritable Stochastic Switching Revealed by Single-Cell Genealogy 

      Kaufmann, Benjamin Bailey; Yang, Qiong; Mettetal, Jerome T; van Oudenaarden, Alexander (Public Library of Science, 2007)
      The partitioning and subsequent inheritance of cellular factors like proteins and RNAs is a ubiquitous feature of cell division. However, direct quantitative measures of how such nongenetic inheritance affects subsequent ...

    • High-Resolution Mutation Mapping Reveals Parallel Experimental Evolution in Yeast 

      Segrè, Ayellet V; Murray, Andrew W.; Leu, Jun-Yi (Public Library of Science, 2006)
      Understanding the genetic basis of evolutionary adaptation is limited by our ability to efficiently identify the genomic locations of adaptive mutations. Here we describe a method that can quickly and precisely map the ...

    • Invasive Plant Suppresses the Growth of Native Tree Seedlings by Disrupting Belowground Mutualisms 

      Stinson, Kristina A.; Campbell, Stuart A; Powell, Jeff R; Wolfe, Benjamin E.; Callaway, Ragan M; Thelen, Giles C; Hallett, Steven G; Prati, Daniel; Klironomos, John N (Public Library of Science, 2006)
      The impact of exotic species on native organisms is widely acknowledged, but poorly understood. Very few studies have empirically investigated how invading plants may alter delicate ecological interactions among resident ...

    • Mucosal Damage and Neutropenia Are Required for Candida albicans Dissemination 

      Koh, Andrew Y; Köhler, Julia R; Coggshall, Kathleen T; Van Rooijen, Nico; Pier, Gerald B. (Public Library of Science, 2008)
      Candida albicans fungemia in cancer patients is thought to develop from initial gastrointestinal (GI) colonization with subsequent translocation into the bloodstream after administration of chemotherapy. It is unclear what ...