Browsing by Keyword "yeast and fungal models"

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    • Iwr1 Protein Is Important for Preinitiation Complex Formation by All Three Nuclear RNA Polymerases in \(Saccharomyces\) \(cerevisiae\) 

      Esberg, Anders; Moqtaderi, Zarmik; Fan, Xiaochun; Lu, Jian; Struhl, Kevin; Byström, Anders (Public Library of Science, 2011)
      Background: Iwr1, a protein conserved throughout eukaryotes, was originally identified by its physical interaction with RNA polymerase (Pol) II. Principal Findings: Here, we identify Iwr1 in a genetic screen designed to ...

    • A Yeast Model of FUS/TLS-Dependent Cytotoxicity 

      Ju, Shulin; Tardiff, Daniel F.; Han, Haesun; Divya, Kanneganti; Maquat, Lynne E.; Bosco, Daryl A.; Hayward, Lawrence J.; Lindquist, Susan; Weissman, Jonathan S.; Zhong, Quan; Brown, Robert H.; Ringe, Dagmar; Petsko, Gregory A. (Public Library of Science, 2011)
      FUS/TLS is a nucleic acid binding protein that, when mutated, can cause a subset of familial amyotrophic lateral sclerosis (fALS). Although FUS/TLS is normally located predominantly in the nucleus, the pathogenic mutant ...