Browsing by Keyword "p16INK4a"

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    • Somatic p16INK4a Loss Accelerates Melanomagenesis 

      Monahan, K B; Rozenberg, G I; Krishnamurthy, J; Johnson, S M; Liu, W; Bradford, M K; Horner, James W.; DePinho, Ronald A.; Sharpless, N E (Nature Publishing Group, 2010)
      Loss of p16\(^{INK4a}–RB\) and ARF–p53 tumor suppressor pathways, as well as activation of RAS–RAF signaling, is seen in a majority of human melanomas. Although heterozygous germline mutations of p16\(^{INK4a}\) are ...