Browsing by Keyword "Yeast and Fungal Models"

Now showing items 1-8 of 8

    • Anion Exchanger 2 Regulates Dectin-1-Dependent Phagocytosis and Killing of Candida albicans 

      Urso, Katia; Charles, Julia F.; Shull, Gary E.; Aliprantis, Antonios O.; Balestrieri, Barbara (Public Library of Science, 2016)
      Anion exchanger 2 (Ae2; gene symbol, Slc4a2) is a plasma membrane Cl-/HCO3- exchanger expressed in the gastrointestinal tract, kidney and bone. We have previously shown that Ae2 is required for the function of osteoclasts, ...

    • Cooperation and the Fate of Microbial Societies 

      Allen, Benjamin Isaac; Nowak, Martin A. (Public Library of Science, 2013)
      Microorganisms have been cooperating with each other for billions of years: by sharing resources, communicating with each other, and joining together to form biofilms and other large structures. These cooperative behaviors ...

    • Induction of Biogenic Magnetization and Redox Control by a Component of the Target of Rapamycin Complex 1 Signaling Pathway 

      Nishida, Keiji; Silver, Pamela A. (Public Library of Science, 2012)
      Most organisms are simply diamagnetic, while magnetotactic bacteria and migratory animals are among organisms that exploit magnetism. Biogenic magnetization not only is of fundamental interest, but also has industrial ...

    • Intracellular Water Exchange for Measuring the Dry Mass, Water Mass and Changes in Chemical Composition of Living Cells 

      Feijó Delgado, Francisco; Cermak, Nathan; Hecht, Vivian C.; Son, Sungmin; Li, Yingzhong; Knudsen, Scott M.; Olcum, Selim; Higgins, John M.; Chen, Jianzhu; Grover, William H.; Manalis, Scott R. (Public Library of Science, 2013)
      We present a method for direct non-optical quantification of dry mass, dry density and water mass of single living cells in suspension. Dry mass and dry density are obtained simultaneously by measuring a cell’s buoyant ...

    • Passing Messages between Biological Networks to Refine Predicted Interactions 

      Glass, Kimberly; Huttenhower, Curtis; Quackenbush, John; Yuan, Guo-Cheng (Public Library of Science, 2013)
      Regulatory network reconstruction is a fundamental problem in computational biology. There are significant limitations to such reconstruction using individual datasets, and increasingly people attempt to construct networks ...

    • A Predictive Model for Yeast Cell Polarization in Pheromone Gradients 

      Muller, Nicolas; Piel, Matthieu; Calvez, Vincent; Voituriez, Raphaël; Gonçalves-Sá, Joana; Guo, Chin-Lin; Jiang, Xingyu; Murray, Andrew; Meunier, Nicolas (Public Library of Science, 2016)
      Budding yeast cells exist in two mating types, a and α, which use peptide pheromones to communicate with each other during mating. Mating depends on the ability of cells to polarize up pheromone gradients, but cells also ...

    • Reconstruction and Validation of a Genome-Scale Metabolic Model for the Filamentous Fungus Neurospora crassa Using FARM 

      Dreyfuss, Jonathan M.; Zucker, Jeremy D.; Hood, Heather M.; Ocasio, Linda R.; Sachs, Matthew S.; Galagan, James E. (Public Library of Science, 2013)
      The filamentous fungus Neurospora crassa played a central role in the development of twentieth-century genetics, biochemistry and molecular biology, and continues to serve as a model organism for eukaryotic biology. Here, ...

    • A Role for FACT in Repopulation of Nucleosomes at Inducible Genes 

      Voth, Warren P.; Takahata, Shinya; Nishikawa, Joy L.; Metcalfe, Benjamin M.; Näär, Anders M.; Stillman, David J. (Public Library of Science, 2014)
      Xenobiotic drugs induce Pleiotropic Drug Resistance (PDR) genes via the orthologous Pdr1/Pdr3 transcription activators. We previously identified the Mediator transcription co-activator complex as a key target of Pdr1 ...