Browsing by Keyword "T cell exhaustion"
Now showing items 1-5 of 5
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Chimeric antigen receptor T cells secreting anti-PD-L1 antibodies more effectively regress renal cell carcinoma in a humanized mouse model
(Impact Journals LLC, 2016)Advances in the treatment of metastatic clear cell renal cell carcinoma (ccRCC) have led to improved progression-free survival of many patients; however the therapies are toxic, rarely achieve durable long-term complete ... -
Deletion of an exhaustion-specific PD-1 enhancer modulates CD8+ T cell fate and function
(2022-09-06)Exhaustion is a state of CD8+ T cell dysfunction arising during chronic viral infection and cancer. Exhausted T cells are less proliferative and less cytotoxic, produce less cytokine, and express high levels of co-inhibitory ... -
Engineering the Epigenetic Regulatory Networks of T Cell Exhaustion and Embryonic Stem Cell Differentiation with Transcription Factor Perturbations
(2024-03-12)The complex interplay of epigenetic factors including chromatin remodeling, histone modifications, and transcription factor binding regulate gene expression and therefore give rise to the diversity of cells within the human ... -
The PD1:PD-L1/2 Pathway from Discovery to Clinical Implementation
(Frontiers Media S.A., 2016)The immune system maintains a critically organized network to defend against foreign particles, while evading self-reactivity simultaneously. T lymphocytes function as effectors and play an important regulatory role to ... -
Understanding anti-leukemia responses to donor lymphocyte infusion
(Landes Bioscience, 2014)Donor lymphocyte infusion (DLI) is an established and potentially curative immune therapy for relapsed leukemia after hematopoietic stem cell transplant (HSCT). Herein, we describe the utility of DLI as a tractable model ...